ArticleMolecular ecology2013
Exploring local immunological adaptation of two stickleback ecotypes by experimental infection and transcriptome-wide digital gene expression analysis.
Article in Molecular ecology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Eco-Evolutionary Dynamics of Infection and Immunity in Experimentally Founded Lake Populations of Threespine Stickleback.The American naturalist · 2026Article
- Article
- Changes in gene regulation are associated with the evolution of resistance to a novel parasite.Frontiers in immunology · 2026Article
- Transcriptomic Divergence and Associated Markers Between Genomic Lineages of Silver Catfish (Ecology and evolution · 2025Article
- Article
- Ecological Speciation Promoted by Divergent Regulation of Functional Genes Within African Cichlid Fishes.Molecular biology and evolution · 2022Article
- Invasion history shapes host transcriptomic response to a body-snatching parasite.Molecular ecology · 2021Article
- An assessment of terminology for intraspecific diversity in fishes, with a focus on "ecotypes" and "life histories".Ecology and evolution · 2021Review
- Review
- Immunogenetic and tolerance strategies against a novel parasitoid of wild field crickets.Ecology and evolution · 2020Article
- A combined transcriptomic approach to identify candidates for an anti-tick vaccine blocking B. afzelii transmission.Scientific reports · 2020Article
- Experimental Parasite Infection Causes Genome-Wide Changes in DNA Methylation.Molecular biology and evolution · 2020Article
- Two different epigenetic information channels in wild three-spined sticklebacks are involved in salinity adaptation.Science advances · 2020Article
- Polymorphism of MHC class IIB in an acheilognathid species, Rhodeus sinensis shaped by historical selection and recombination.BMC genetics · 2019Article
- Characterization and analysis of the transcriptome in Gymnocypris selincuoensis on the Qinghai-Tibetan Plateau using single-molecule long-read sequencing and RNA-seq.DNA research : an international journal for rapid publication of reports on genes and genomes · 2019Article
- Genome-Wide Genotype-Expression Relationships Reveal Both Copy Number and Single Nucleotide Differentiation Contribute to Differential Gene Expression between Stickleback Ecotypes.Genome biology and evolution · 2019Article
- The right response at the right time: Exploring helminth immune modulation in sticklebacks by experimental coinfection.Molecular ecology · 2019Article
- Specificity of resistance and geographic patterns of virulence in a vertebrate host-parasite system.BMC evolutionary biology · 2019Article
- Article
- Genomic associations with bill length and disease reveal drift and selection across island bird populations.Evolution letters · 2018Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the extent of local adaptation in natural populations and the mechanisms that allow individuals to adapt to their native environment is a major avenue in molecular ecology research. Evidence for the frequent occurrence of diverging ecotypes in species that inhabit multiple ecological habitats is accumulating, but experimental approaches to understanding the biological pathways as well as the underlying genetic mechanisms are still rare. Parasites are invoked as one of the major selective forces driving evolution and are themselves dependent on the ecological conditions in a given habitat. Immunological adaptation to local parasite communities is therefore expected to be a key component of local adaptation in natural populations. Here, we use next-generation sequencing technology to compare the transcriptome-wide response of experimentally infected three-spined sticklebacks from a lake and a river population, which are known to evolve under selection by distinct parasite communities. By comparing overall gene expression levels as well as the activation of functional pathways in response to parasite exposure, we identified potential differences between the two stickleback populations at several levels. Our results suggest locally adapted patterns of gene regulation in response to parasite exposure, which may reflect different local optima in the trade-off between the benefits and the disadvantages of mounting an immune response because of quantitative differences of the local parasite communities.
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