ArticleNeural computation2012
Tuning low-voltage-activated A-current for silent gain modulation.
Article in Neural computation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Article
- Gain control with A-type potassium current: IA as a switch between divisive and subtractive inhibition.PLoS computational biology · 2018Article
- Inhibitory modulation of optogenetically identified neuron subtypes in the rostral solitary nucleus.Journal of neurophysiology · 2016Article
- Mechanisms of gain control by voltage-gated channels in intrinsically-firing neurons.PloS one · 2015Article
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Authors and funding
3 authors.
Funding
Abstract
Modulation of stimulus-response gain and stability of spontaneous (unstimulated) firing are both important for neural computation. However, biologically plausible mechanisms that allow these distinct functional capabilities to coexist in the same neuron are poorly defined. Low-threshold, inactivating (A-type) K(+) currents (I(A)) are found in many biological neurons and are historically known for enabling low-frequency firing. By performing simulations using a conductance-based model neuron, here we show that biologically plausible shifts in I(A) conductance and inactivation kinetics produce dissociated effects on gain and intrinsic firing. This enables I(A) to regulate gain without major changes in intrinsic firing rate. Tuning I(A) properties may thus represent a previously unsuspected single-current mechanism of silent gain control in neurons.
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