Trial reportJournal of pregnancy2012
Podocyturia as a diagnostic marker for preeclampsia amongst high-risk pregnant patients.
Trial report in Journal of pregnancy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Urinary Podocyte Loss is Associated With Treatment Response in Patients With Primary Nephrotic Syndrome.Kidney international reports · 2026Article
- Kidney health outcomes of hypertensive disorders of pregnancy.Nature reviews. Nephrology · 2025Review
- Podocyturia an emerging biomarker for kidney injury.BMC nephrology · 2025Review
- Mechanisms of Podocyte Detachment, Podocyturia, and Risk of Progression of Glomerulopathies.Kidney diseases (Basel, Switzerland) · 2020Review
- Antigen Analysis of Pre-Eclamptic Plasma Antibodies UsingMolecular & cellular proteomics : MCP · 2018Article
- Preeclampsia: Novel Mechanisms and Potential Therapeutic Approaches.Frontiers in physiology · 2018Review
- Extracellular Vesicles in Preeclampsia: Evolving Contributors to Proteinuria.Journal of the American Society of Nephrology : JASN · 2017Article
- Podocyturia: Potential applications and current limitations.World journal of nephrology · 2017Review
- Podocytes from the diagnostic and therapeutic point of view.Pflugers Archiv : European journal of physiology · 2017Review
- The effects of sildenafil citrate on urinary podocin and nephrin mRNA expression in an L-NAME model of pre-eclampsia.Molecular and cellular biochemistry · 2017Article
- Podocyturia is significantly elevated in untreated vs treated Fabry adult patients.Journal of nephrology · 2016Observational
- Hypertension in Pregnancy: Defining Blood Pressure Goals and the Value of Biomarkers for Preeclampsia.Current cardiology reports · 2016Review
- Alteration of podocyte phenotype in the urine of women with preeclampsia.Scientific reports · 2016Article
- Endoglin regulates mural cell adhesion in the circulatory system.Cellular and molecular life sciences : CMLS · 2016Article
- Prediction of preeclampsia-bench to bedside.Current hypertension reports · 2014Review
- The role of the podocyte in preeclampsia.Clinical journal of the American Society of Nephrology : CJASN · 2014Article
- Advances in the pathophysiology of pre-eclampsia and related podocyte injury.Kidney international · 2014Review
- A comparison of podocyturia, albuminuria and nephrinuria in predicting the development of preeclampsia: a prospective study.PloS one · 2014Article
- Persistent urinary podocyte loss following preeclampsia may reflect subclinical renal injury.PloS one · 2014Article
- Proteinuria in preeclampsia from a podocyte injury perspective.Current hypertension reports · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Urinary podocyte (podocyturia) has been studied as a diagnostic marker for preeclampsia. We sought to validate its use in preeclampsia and in differentiating it from other high risk pregnancy states. We studied an obstetric population at high risk to develop preeclampsia (study group) and uncomplicated pregnancies (control group) by analyzing their urine sediment for podocytes within 24 hours of delivery. Podocytes were identified by immunohistochemistry using the podocyte-specific protein synaptopodin. Of the 56 patients who were enrolled, 29 patients were diagnosed with preeclampsia, 9 patients had hypertensive conditions such as chronic and gestational hypertension, 6 patients had Type I/II and gestational diabetes mellitus, 3 patients were classified as others, and 9 patients exhibited uncomplicated pregnancies. Podocyturia was identified in 11 out of 29 (38%) of patients with preeclampsia/eclampsia, 3 out of 9 (33%) with gestational and chronic hypertension, and 3 out of 6 (50%) with Type I/II and gestational diabetes mellitus. None of the 9 patients (0%) with uncomplicated pregnancies demonstrated podocyturia. The sensitivity and specificity of podocyturia for preeclampsia were found to be 38% and 70%. Our study showed that podocyturia does not appear to be a sensitive nor a specific marker to diagnose preeclampsia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.