ArticleJournal of parasitology research2012
Transmission of onchocerciasis in wadelai focus of northwestern Uganda has been interrupted and the disease eliminated.
Article in Journal of parasitology research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Elimination of transmission of onchocerciasis (river blindness) with long-term ivermectin mass drug administration with or without vector control in sub-Saharan Africa: a systematic review and meta-analysis.The Lancet. Global health · 2024Pooled it
- Article
- Mass drug administration coverage and its determinants for the elimination of onchocerciasis in Ulanga District, Tanzania.PLoS neglected tropical diseases · 2025Article
- The Impact of Onchocerciasis Elimination Measures in Africa: A Systematic Review.Tropical medicine and infectious disease · 2024Review
- Do Residents Believe that Onchocerciasis Transmission Was Eliminated? Results of A Post-Treatment Surveillance Knowledge, Attitude, and Practices Survey in Three Foci of Uganda.The American journal of tropical medicine and hygiene · 2024Article
- Comparison of standard and modified human landing catching techniques for blackfly collection.International health · 2024Article
- Article
- The burden of skin disease and eye disease due to onchocerciasis in countries formerly under the African Programme for Onchocerciasis Control mandate for 1990, 2020, and 2030.PLoS neglected tropical diseases · 2021Article
- Status of parasitological indicators and morbidity burden of onchocerciasis after years of successive implementation of mass distribution of ivermectin in selected communities of Yeki and Asosa districts, Ethiopia.BMC public health · 2020Article
- Accelerating river blindness elimination by supplementing MDA with a vegetation "slash and clear" vector control strategy: a data-driven modeling analysis.Scientific reports · 2019Article
- Predictive Value of Ov16 Antibody Prevalence in Different Subpopulations for Elimination of African Onchocerciasis.American journal of epidemiology · 2019Article
- The role of health animators in malaria control: a qualitative study of the health animator (HA) approach within the Majete malaria project (MMP) in Chikwawa District, Malawi.BMC health services research · 2019Article
- Reaching the last mile: main challenges relating to and recommendations to accelerate onchocerciasis elimination in Africa.Infectious diseases of poverty · 2019Review
- Inflammatory and regulatory CCL and CXCL chemokine and cytokine cellular responses in patients with patent Mansonella perstans filariasis.Clinical and experimental immunology · 2019Article
- Neurological manifestations in Onchocerca volvulus infection: A review.Brain research bulletin · 2019Review
- Community-directed vector control to supplement mass drug distribution for onchocerciasis elimination in the Madi mid-North focus of Northern Uganda.PLoS neglected tropical diseases · 2018Article
- How Can Onchocerciasis Elimination in Africa Be Accelerated? Modeling the Impact of Increased Ivermectin Treatment Frequency and Complementary Vector Control.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
- Comparison of PCR Methods forThe American journal of tropical medicine and hygiene · 2018Article
- Interruption of onchocerciasis transmission in Bioko Island: Accelerating the movement from control to elimination in Equatorial Guinea.PLoS neglected tropical diseases · 2018Article
- Elimination of onchocerciasis from Colombia: first proof of concept of river blindness elimination in the world.Parasites & vectors · 2018Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wadelai, an isolated focus for onchocerciasis in northwest Uganda, was selected for piloting an onchocerciasis elimination strategy that was ultimately the precursor for countrywide onchocerciasis elimination policy. The Wadelai focus strategy was to increase ivermectin treatments from annual to semiannual frequency and expand geographic area in order to include communities with nodule rate of less than 20%. These communities had not been covered by the previous policy that sought to control onchocerciasis only as a public health problem. From 2006 to 2010, Wadelai program successfully attained ultimate treatment goal (UTG), treatment coverage of ≥90%, despite expanding from 19 to 34 communities and from 5,600 annual treatments to over 29,000 semiannual treatments. Evaluations in 2009 showed no microfilaria in skin snips of over 500 persons examined, and only 1 of 3011 children was IgG4 antibody positive to the OV16 recombinant antigen. No Simulium vectors were found, and their disappearance could have sped up interruption of transmission. Although twice-per-year treatment had an unclear role in interruption of transmission, the experience demonstrated that twice-per-year treatment is feasible in the Ugandan setting. The monitoring data support the conclusion that onchocerciasis has been eliminated from the Wadelai focus of Uganda.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.