ArticlePloS one2012
Distinct functional patterns of gene promoter hypomethylation and hypermethylation in cancer genomes.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- Targeting the crosstalk of epigenetic modifications and immune evasion in nasopharyngeal cancer.Cell biology and toxicology · 2023Review
- Review
- Article
- IL10 hypomethylation is associated with the risk of gastric cancer.Oncology letters · 2021Article
- Crosstalk Between Inflammatory Signaling and Methylation in Cancer.Frontiers in cell and developmental biology · 2021Review
- Characterization of the prognostic and oncologic values of ITGB superfamily members in pancreatic cancer.Journal of cellular and molecular medicine · 2020Article
- Article
- Epigenetic Changes Associated With Interleukin-10.Frontiers in immunology · 2020Review
- Epigenetic regulation of inflammatory cytokines and associated genes in human malignancies.Mediators of inflammation · 2015Review
- Separate enrichment analysis of pathways for up- and downregulated genes.Journal of the Royal Society, Interface · 2014Article
- Coregulation and modulation of NFκB-related genes in celiac disease: uncovered aspects of gut mucosal inflammation.Human molecular genetics · 2014Article
- DNA methyltransferases and TETs in the regulation of differentiation and invasiveness of extra-villous trophoblasts.Frontiers in genetics · 2013Review
- Article
- RETRACTED: Role of DNA methylation in cell cycle arrest induced by Cr (VI) in two cell lines.PloS one · 2013Article
- Gene × environment interaction by a longitudinal epigenome-wide association study (LEWAS) overcomes limitations of genome-wide association study (GWAS).Epigenomics · 2012Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAberrant DNA methylation plays important roles in carcinogenesis. However, the functional significance of genome-wide hypermethylation and hypomethylation of gene promoters in carcinogenesis currently remain unclear. PRINCIPAL
findingsBased on genome-wide methylation data for five cancer types, we showed that genes with promoter hypermethylation were highly consistent in function across different cancer types, and so were genes with promoter hypomethylation. Functions related to "developmental processes" and "regulation of biology processes" were significantly enriched with hypermethylated genes but were depleted of hypomethylated genes. In contrast, functions related to "cell killing" and "response to stimulus", including immune and inflammatory response, were associated with an enrichment of hypomethylated genes and depletion of hypermethylated genes. We also observed that some families of cytokines secreted by immune cells, such as IL10 family cytokines and chemokines, tended to be hypomethylated in various cancer types. These results provide new hints for understanding the distinct functional roles of genome-wide hypermethylation and hypomethylation of gene promoters in carcinogenesis.
conclusionsGenes with promoter hypermethylation and hypomethylation are highly consistent in function across different cancer types, respectively, but these two groups of genes tend to be enriched in different functions associated with cancer. Especially, we speculate that hypomethylation of gene promoters may play roles in inducing immunity and inflammation disorders in precancerous conditions, which may provide hints for improving epigenetic therapy and immunotherapy of cancer.
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