ArticlePloS one2012
Direct behavioral evidence for retronasal olfaction in rats.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Multisensory Integration Underlies the Distinct Representation of Odor-Taste Mixtures in the Gustatory Cortex of Behaving Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- An intra-oral flavor detection task in freely moving mice.iScience · 2024Article
- The role of the mediodorsal thalamus in chemosensory preference and consummatory behavior in rats.Chemical senses · 2024Article
- Odor modality is transmitted to cortical brain regions from the olfactory bulb.Journal of neurophysiology · 2023Article
- Article
- Cortical Hub for Flavor Sensation in Rodents.Frontiers in systems neuroscience · 2021Review
- Impact of menthol on nicotine intake and preference in mice: Concentration, sex, and age differences.Neuropharmacology · 2020Article
- Experience Informs Consummatory Choices for Congruent and Incongruent Odor-Taste Mixtures in Rats.Chemical senses · 2020Article
- Article
- Retronasal Odor Perception Requires Taste Cortex, but Orthonasal Does Not.Current biology : CB · 2019Article
- Experience-dependent c-Fos expression in the primary chemosensory cortices of the rat.Brain research · 2018Article
- How to monitor breathing in laboratory rodents: a review of the current methods.Journal of neurophysiology · 2018Review
- Single-neuron responses to intraoral delivery of odor solutions in primary olfactory and gustatory cortex.Journal of neurophysiology · 2017Article
- Processing of Intraoral Olfactory and Gustatory Signals in the Gustatory Cortex of Awake Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Comparison of glomerular activity patterns by fMRI and wide-field calcium imaging: Implications for principles underlying odor mapping.NeuroImage · 2016Article
- A role for lung retention in the sense of retronasal smell.Chemosensory perception · 2015Article
- Article
- Identification of odorant-receptor interactions by global mapping of the human odorome.PloS one · 2014Article
- Retronasal odor concentration coding in glomeruli of the rat olfactory bulb.Frontiers in integrative neuroscience · 2014Article
- Glomerular input patterns in the mouse olfactory bulb evoked by retronasal odor stimuli.BMC neuroscience · 2013Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The neuroscience of flavor perception is becoming increasingly important to understand abnormal feeding behaviors and associated chronic diseases such as obesity. Yet, flavor research has mainly depended on human subjects due to the lack of an animal model. A crucial step towards establishing an animal model of flavor research is to determine whether the animal uses the retronasal mode of olfaction, an essential element of flavor perception. We designed a go- no go behavioral task to test the rat's ability to detect and discriminate retronasal odorants. In this paradigm, tasteless aqueous solutions of odorants were licked by water-restricted head-fixed rats from a lick spout. Orthonasal contamination was avoided by employing a combination of a vacuum around the lick-spout and blowing clean air toward the nose. Flow models support the effectiveness of both approaches. The licked odorants were successfully discriminated by rats. Moreover, the tasteless odorant amyl acetate was reliably discriminated against pure distilled water in a concentration-dependent manner. The results from this retronasal odor discrimination task suggest that rats are capable of smelling retronasally. This direct behavioral evidence establishes the rat as a useful animal model for flavor research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.