ArticlePloS one2012
Virulence profiles of bacteremic extended-spectrum β-lactamase-producing Escherichia coli: association with epidemiological and clinical features.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- A matched case-control study on Escherichia coli factors contributing to sepsis and septic shock in bacteraemic patients.Communications medicine · 2026Article
- Molecular Characterization of High and Low VirulentInfection and drug resistance · 2024Article
- Comparison of phylogenetic and virulence factors betweenHeliyon · 2023Article
- Molecular epidemiology of blaAnnals of clinical microbiology and antimicrobials · 2021Article
- Pathogenesis of Gram-Negative Bacteremia.Clinical microbiology reviews · 2021Review
- The prevalence of the iutA and ibeA genes in Escherichia coli isolates from severe and non-severe patients with bacteremic acute biliary tract infection is significantly different.Gut pathogens · 2021Article
- Diversity, Virulence, and Clinical Significance of Extended-Spectrum β-Lactamase- and pAmpC-ProducingFrontiers in microbiology · 2019Article
- Sequence Types, Clonotypes, Serotypes, and Virotypes of Extended-Spectrum β-Lactamase-ProducingFrontiers in microbiology · 2019Article
- Bloodstream infections caused by Escherichia coli producing AmpC β-lactamases: epidemiology and clinical features.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016Article
- Gut Colonization of Healthy Children and Their Mothers With Pathogenic Ciprofloxacin-Resistant Escherichia coli.The Journal of infectious diseases · 2015Article
- Insight into neonatal septicaemic Escherichia coli from India with respect to phylogroups, serotypes, virulence, extended-spectrum-β-lactamases and association of ST131 clonal group.Epidemiology and infection · 2015Article
- Phylogenetic Distribution of Virulence Genes Among ESBL-producing Uropathogenic Escherichia coli Isolated from Long-term Hospitalized Patients.Journal of clinical and diagnostic research : JCDR · 2015Article
- Impact of virulence genes on sepsis severity and survival in Escherichia coli bacteremia.Virulence · 2015Article
- Assessment of Adhesins as an Indicator of Pathovar-Associated Virulence Factors in Bovine Escherichia coli.Applied and environmental microbiology · 2014Article
- Long-term dissemination of acquired AmpC β-lactamases among Klebsiella spp. and Escherichia coli in Portuguese clinical settings.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014Article
- Differences in extended-spectrum beta-lactamase producing Escherichia coli virulence factor genes in the Baltic Sea region.BioMed research international · 2014Article
- Human and avian extraintestinal pathogenic Escherichia coli: infections, zoonotic risks, and antibiotic resistance trends.Foodborne pathogens and disease · 2013Review
- Epidemiological and clinical complexity of amoxicillin-clavulanate-resistant Escherichia coli.Journal of clinical microbiology · 2013Article
- Commensal Enterobacteriaceae as reservoirs of extended-spectrum beta-lactamases, integrons, and sul genes in Portugal.Frontiers in microbiology · 2013Article
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Authors and funding
7 authors.
Funding
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Abstract
There is scarce data about the importance of phylogroups and virulence factors (VF) in bloodstream infections (BSI) caused by extended-spectrum β-lactamase-producing Escherichia coli (ESBLEC). A prospective multicenter Spanish cohort including 191 cases of BSI due to ESBLEC was studied. Phylogroups and 25 VF genes were investigated by PCR. ESBLEC were classified into clusters according to their virulence profiles. The association of phylogropus, VF, and clusters with epidemiological features were studied using multivariate analysis. Overall, 57.6%, 26.7%, and 15.7% of isolates belonged to A/B1, D and B2 phylogroups, respectively. By multivariate analysis (adjusted OR [95% CI]), virulence cluster C2 was independently associated with urinary tract source (5.05 [0.96-25.48]); cluster C4 with sources other than urinary of biliary tract (2.89 [1.05-7.93]), and cluster C5 with BSI in non-predisposed patients (2.80 [0.99-7.93]). Isolates producing CTX-M-9 group ESBLs and from phylogroup D predominated among cluster C2 and C5, while CTX-M-1 group of ESBL and phylogroup B2 predominantes among C4 isolates. These results suggest that host factors and previous antimicrobial use were more important than phylogroup or specific VF in the occurrence of BSI due to ESBLEC. However, some associations between virulence clusters and some specific epidemiological features were found.
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