ArticleExperimental and therapeutic medicine2012
The TNF-α-308G/A polymorphism is associated with migraine risk: A meta-analysis.
Article in Experimental and therapeutic medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 5 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Comprehensive analysis of genes associated with migraine in the Indian population: a meta-analysis of genetic association studies with trial sequential analysis.Scientific reports · 2023Pooled it
- Enlightening the association between TNF-α -308 G > A and migraine: a meta-analysis with meta-regression and trial sequential analysis.BMC neurology · 2023Pooled it
- Pooled it
- Genetic variants in migraine: a field synopsis and systematic re-analysis of meta-analyses.The journal of headache and pain · 2020Pooled it
- Tumor Necrosis Factor (TNF) -308G>A, Nitric Oxide Synthase 3 (NOS3) +894G>T Polymorphisms and Migraine Risk: A Meta-Analysis.PloS one · 2015Pooled it
- Correlation of tumor necrosis factor-α and interleukin-1 single-nucleotide polymorphisms with the risk of migraine development.Frontiers in genetics · 2025Article
- Altered immunity in migraine: a comprehensive scoping review.The journal of headache and pain · 2024Article
- Experimental and Clinical Investigation of Cytokines in Migraine: A Narrative Review.International journal of molecular sciences · 2023Review
- Relationship between vitamin D receptor gene polymorphisms and migraine without aura in an Iranian population.BioMed research international · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Migraine is a neurasthenia and the genetic etiology has not been determined. Several studies concerning the correlation between the tumor necrosis factor (TNF)-α-308G/A polymorphism and migraine have been published, but their results remain controversial and the small samples in each study do not allow sufficient statistical power. In the present study, odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the association between the polymorphism and migraine. An inverse-variance method was applied to estimate the frequency of the putative risk allele in the controls. Heterogeneity was determined using Cochran's Q test and the inconsistency index (I(2)). Begg's test and the inverted funnel plot were used to assess the publication bias. Five studies on Asian populations, comprising 985 cases and 958 controls, were included in the meta-analysis. The overall results revealed that the TNF-α-308G/A polymorphism was associated with migraine risk in Asians. The ORs were 1.735 (95% CI, 1.129-2.666) for A vs. G; 1.781 (95% CI, 1.166-2.718) for GA vs. GG; 1.821 (95% CI, 1.153-2.874) for AA+GA vs. GG. The subgroup analysis was based on migraine with aura (MA) and migraine without aura (MO) and there was a statistically significant result for MA [the OR was 1.728 (95% CI, 1.095-2.726) for GA vs. GG and 1.651 (95% CI, 1.049-2.598) for AA+GA vs. GG] but not for MO. In conclusion, the TNF-α -308G/A polymorphism was associated with migraine risk.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.