ArticleExperimental and therapeutic medicine2012
Diagnostic accuracy of vascular endothelial growth factor for malignant pleural effusion: A meta-analysis.
Article in Experimental and therapeutic medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 5 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 5 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Diagnostic accuracy of the cancer ratio for the prediction of malignant pleural effusion: evidence from a validation study and meta-analysis.Annals of medicine · 2021Pooled it
- Systematic review and meta-analysis of vascular endothelial growth factor as a biomarker for malignant pleural effusions.Physiological reports · 2016Pooled it
- Diagnostic value of thyroid transcription factor-1 for pleural or other serous metastases of pulmonary adenocarcinoma: a meta-analysis.Scientific reports · 2016Pooled it
- Can cholesterol be used to distinguish pleural exudates from transudates? evidence from a bivariate meta-analysis.BMC pulmonary medicine · 2014Pooled it
- Diagnostic value of survivin for malignant pleural effusion: a clinical study and meta-analysis.International journal of clinical and experimental pathology · 2014Pooled it
- Interleukin -39 Expression in Pleural Effusion and Its Diagnostic Value for Tuberculous Pleurisy.Journal of inflammation research · 2025Article
- Malignant pleural disease.Breathe (Sheffield, England) · 2023Review
- Pleural biomarkers in diagnostics of malignant pleural effusion: a narrative review.Translational lung cancer research · 2021Review
- Hemorrhagic Malignant Pleural Effusion: Diagnosis, Survival Rate, and Response to Talc Pleurodesis.Indian journal of surgical oncology · 2021Article
- The importance of serum and pleural fluid level of vascular endothelial growth factor (VEGF) and VEGF fluid/serum ratio in the differential diagnosis of malignant mesothelioma-related pleural effusion.Contemporary oncology (Poznan, Poland) · 2017Article
- Closing faucets: the role of anti-angiogenic therapies in malignant pleural diseases.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2016Review
- A potential role for VEGF in the diagnostic approach of pleural effusions.Journal of thoracic disease · 2016Article
- Differential expression of vascular endothelial growth factor-A, -C and -D for the diagnosis and prognosis of cancer patients with malignant effusions.Oncology letters · 2015Article
- Article
- Malignant pleural effusion: medical approaches for diagnosis and management.Tuberculosis and respiratory diseases · 2014Review
- The role of vascular endothelial growth factor in the pathogenesis, diagnosis and treatment of malignant pleural effusion.Current oncology reports · 2013Review
- Telomerase activity assay for the diagnosis of malignant pleural effusion: A meta-analysis.Experimental and therapeutic medicine · 2012Article
- Adenosine deaminase-based measurement in the differential diagnosis of pleural effusion: a multicenter retrospective study.Therapeutic advances in respiratory diseaseArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since the diagnostic accuracy of conventional examinations for malignant pleural effusion (MPE) is limited, a number of studies have investigated the utility of pleural vascular endothelial growth factor (VEGF) in the diagnosis of MPE. The present meta-analysis aimed to determine the overall accuracy of a VEGF test in the diagnosis of MPE. A systematic review of studies published in English was conducted and the data concerning the accuracy of pleural VEGF assays in the diagnosis of MPE were pooled with random effects models. The overall test performance was summarized using receiver operating characteristic curves. Ten studies, based on 1,025 patients, met the inclusion criteria for the meta-analysis and the summary estimates for VEGF in the diagnosis of MPE were: sensitivity 0.75 [95% confidence interval (CI), 0.72-0.79], specificity 0.72 (95% CI, 0.68-0.76), positive likelihood ratio 2.94 (95% CI, 1.97-4.41), negative likelihood ratio 0.38 (95% CI, 0.27-0.51) and diagnostic odds ratio 9.05 (95% CI, 4.60-17.80). The summary receiver operating characteristic curve indicated that the maximum joint sensitivity and specificity was 0.75; the area under the curve was 0.82. Our findings suggest that the determination of pleural VEGF may improve the accuracy of MPE diagnosis, while the results of VEGF assays should be interpreted in parallel with conventional test results and other clinical findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.