ArticleExperimental and therapeutic medicine2012
Interaction of Staphylococcus aureus with osteoblasts (Review).
Article in Experimental and therapeutic medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 47 citations in OpenAlex.
- Nanomaterial strategies for antibiotic-resistant infections: Mechanistic frameworks, rational design, and clinical translation.Materials today. Bio · 2026Review
- Synergistic integration of biomaterials in orthopedic implantation for infection preventing and tissue engineering.Regenerative biomaterials · 2026Review
- Implant-DerivedAntibiotics (Basel, Switzerland) · 2025Article
- From macrophage polarization to clinical translation: immunomodulatory hydrogels for infection-associated bone regeneration.Frontiers in cell and developmental biology · 2025Review
- Dual-functional composite scaffolds for inhibiting infection and promoting bone regeneration.Materials today. Bio · 2022Review
- Osteocytes directly regulate osteolysis via MYD88 signaling in bacterial bone infection.Nature communications · 2022Article
- Delayed union, non-union and mal-union in 442 dogs.Veterinary surgery : VS · 2022Article
- Novel therapeutic interventions towards improved management of septic arthritis.BMC musculoskeletal disorders · 2021Review
- Review
- Different Modulatory Effects of Four Methicillin-ResistantBiomolecules · 2021Article
- Advantages of 16S rRNA PCR for the diagnosis of prosthetic joint infection.Experimental and therapeutic medicine · 2020Article
- Attempts to TargetMolecules (Basel, Switzerland) · 2020Article
- Effects of staphylococcal infection and aseptic inflammation on bone mass and biomechanical properties in a rabbit model.Journal of orthopaedic translation · 2020Article
- Bacterial Biofilm Components Induce an Enhanced Inflammatory Response Against Metal Wear Particles.Therapeutics and clinical risk management · 2020Article
- Methods Used for the Eradication of Staphylococcal Biofilms.Antibiotics (Basel, Switzerland) · 2019Review
- Adipose-Derived Stromal Cells Are Capable of Restoring Bone Regeneration After Post-Traumatic Osteomyelitis and Modulate B-Cell Response.Stem cells translational medicine · 2019Article
- In-vivo monitoring of infectious diseases in living animals using bioluminescence imaging.Virulence · 2018Review
- Article
- Article
- Visual Pattern and Serial Quantitation ofNuclear medicine and molecular imaging · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Orthopedic infection is refractory to cure. Staphylococcus aureus (S. aureus) is the main causative pathogen responsible for orthopedic infection. S. aureus is capable of not only colonizing bone matrix, but also invading osteoblasts, which may play a significant role in the persistence and recurrence of osteomyelitis. Internalization requires the involvement of cytoskeletal elements, including actin microfilaments, microtubules and clathrin-coated pits. Microfilaments are most significant in the invasion process. S. aureus is capable of remaining alive in osteoblasts for a long period of time. Decreased sensitivity to antibiotics capable of penetrating host cells increases the difficulties of eradicating S. aureus. Osteoblasts, invaded by S. aureus, play a significant role in the initiation and maintenance of inflammatory immune responses. These osteoblasts recruit leukocytes and phagocytes to the site of inflammation via the expression of cytokines. Apoptosis is observed in osteoblasts invaded by S. aureus. Recruitment of osteoclasts and other immunocytes plays a crucial role in the resorption and destruction of bone.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.