ArticleExperimental and therapeutic medicine2012
miRNA expression profile in primary gastric cancers and paired lymph node metastases indicates that miR-10a plays a role in metastasis from primary gastric cancer to lymph nodes.
Article in Experimental and therapeutic medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
33 citing papers in PubMed, 66 citations in OpenAlex.
- MicroRNA-10a is down-regulated by DNA methylation and functions as a tumor suppressor in gastric cancer cells.PloS one · 2014Trial
- The Role of microRNAs in Inflammation.International journal of molecular sciences · 2022Review
- The upregulation of circFNDC3B aggravates the recurrence after endoscopic submucosal dissection (ESD) in early gastric cancer (EGC) patients.Scientific reports · 2022Article
- Long non-coding RNA LINRIS is upregulated in non-small cell lung cancer and its silencing inhibits cell proliferation by suppressing microRNA-10a maturation.Bioengineered · 2022Article
- The Lymph Node Microenvironment May Invigorate Cancer Cells With Enhanced Metastatic Capacities.Frontiers in oncology · 2022Article
- DICER-AS1 functions as competing endogenous RNA that targets CSR1 by sponging microRNA-650 and suppresses gastric cancer progression.The Journal of international medical research · 2021Article
- The emerging role of miR-10 family in gastric cancer.Cell cycle (Georgetown, Tex.) · 2021Review
- MiR-10a in Pancreatic Juice as a Biomarker for Invasive Intraductal Papillary Mucinous Neoplasm by miRNA Sequencing.International journal of molecular sciences · 2021Article
- miR-10a overexpression aggravates renal ischemia-reperfusion injury associated with decreased PIK3CA expression.BMC nephrology · 2020Article
- Distinct shed microvesicle and exosome microRNA signatures reveal diagnostic markers for colorectal cancer.PloS one · 2019Article
- NRF1 and NRF2 mRNA and Protein Expression Decrease Early during Melanoma Carcinogenesis: An Insight into Survival and MicroRNAs.Oxidative medicine and cellular longevity · 2019Article
- MiR-1284 suppresses gastric cancer progression by targeting EIF4A1.OncoTargets and therapy · 2019Article
- Epigenetic Field Cancerization in Gastric Cancer: microRNAs as Promising Biomarkers.Journal of Cancer · 2019Article
- miRNA-1284, a regulator of HMGB1, inhibits cell proliferation and migration in osteosarcoma.Bioscience reports · 2018Article
- MiR-10a-5p targets TFAP2C to promote gemcitabine resistance in pancreatic ductal adenocarcinoma.Journal of experimental & clinical cancer research : CR · 2018Article
- MicroRNA-196a-5p is a potential prognostic marker of delayed lymph node metastasis in early-stage tongue squamous cell carcinoma.Oncology letters · 2018Article
- MicroRNAs as potential biomarkers for diagnosis, therapy and prognosis of gastric cancer.OncoTargets and therapy · 2018Review
- Unveiling massive numbers of cancer-related urinary-microRNA candidates via nanowires.Science advances · 2017Article
- miR-10a suppresses colorectal cancer metastasis by modulating the epithelial-to-mesenchymal transition and anoikis.Cell death & disease · 2017Article
- Direct targeting of MAPK8IP1 by miR-10a-5p is a major mechanism for gastric cancer metastasis.Oncology letters · 2017Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to identify and evaluate microRNAs (miRNAs) in gastric cancer lymph node metastasis. A miRNA array was used to compare the expression of miRNAs in primary gastric cancer and paired lymph node metastases. miRNAs found to be differentially expressed were validated in a cohort of primary gastric cancer tissues, and the relationship between expression and the clinicopathological characteristics of the specimens was analyzed. The expression level of miR-10a in a gastric mucosal cell line and three gastric cancer cell lines was also detected using qPCR. Moreover, the target genes for miR-10a were predicted using bioinformatic methods. Based on the results, four differentially expressed miRNAs were detected by the miRNA array. Compared with primary gastric cancer, lymph node metastases displayed downregulated expression of miR-24-1(*), miR-510 and miR-1284, while the expression of miR-10a was upregulated. Consequently, analysis found that the expression of miR-10a was associated with lymph node metastasis (P=0.047), but was independent of the state of lymphatic invasion (P=0.169) in the cohort of primary gastric carcinoma. The expression of miR-10a was at least 10-fold higher in the three gastric cancer cell lines than in the gastric mucosal cell line. Two gastric cancer cell lines, which were established from lymph node metastasis, expressed higher miR-10a compared to the primary tumor origin cell line. Bioinformatic analysis demonstrated that the target genes of miR-10a are involved in multiple related pathways of tumorigenesis and metastasis. In conclusion, our study suggests that miR-10a is involved in the development of gastric cancer and lymph node metastasis, particularly in the latter process.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.