ArticleJournal of cancer epidemiology2012
Serum Lipids and the Risk of Gastrointestinal Malignancies in the Swedish AMORIS Study.
Article in Journal of cancer epidemiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 6 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- A burden of proof study of the effects of exposure to high fasting plasma glucose on the risk of seven types of cancer.Scientific reports · 2025Pooled it
- Association between blood lipid levels and risk of gastric cancer: A systematic review and meta-analysis.PloS one · 2023Pooled it
- Haemoglobin A1c and serum glucose levels and risk of gastric cancer: a systematic review and meta-analysis.British journal of cancer · 2022Pooled it
- Pooled it
- A Linear Dose-Response Relationship between Fasting Plasma Glucose and Colorectal Cancer Risk: Systematic Review and Meta-analysis.Scientific reports · 2015Pooled it
- The association between serum lipids and colorectal neoplasm: a systemic review and meta-analysis.Public health nutrition · 2015Pooled it
- Lipid metabolism in colorectal cancer: dual roles and statin therapy.Discover oncology · 2025Review
- Association of triglyceride-glucose-related indices with all-cause and cause-specific mortality in individuals with prediabetesss.Cardiovascular diabetology · 2025Article
- Serum Lipid Biomarkers and the Risk of Gastrointestinal Cancers in a Chinese Population: The Kailuan Prospective Study.Cancer medicine · 2025Article
- Discrepant effect of high-density lipoprotein cholesterol on esophageal and gastric cancer risk in a nationwide cohort.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2024Article
- Endocrine-disrupting compounds and metabolomic reprogramming in breast cancer.Journal of biochemical and molecular toxicology · 2023Review
- High-density lipoprotein, low-density lipoprotein and triglyceride levels and upper gastrointestinal cancers risk: a trans-ancestry Mendelian randomization study.European journal of clinical nutrition · 2022Article
- Article
- Postoperative high-density lipoprotein cholesterol level: an independent prognostic factor for gastric cancer.Frontiers in oncology · 2022Article
- Nationwide cohort study: cholesterol level is inversely related with the risk of gastric cancer among postmenopausal women.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2022Article
- Fibrinogen-to-Neutrophil Ratio as a New Predictor of Central Lymph Node Metastasis in Patients with Papillary Thyroid Cancer and Type 2 Diabetes Mellitus.Cancer management and research · 2022Article
- Prognostic value of nutritional and inflammatory indicators in females with esophageal squamous cell cancer: A propensity score matching study.Frontiers in genetics · 2022Article
- Independent and opposing associations of dietary phytosterols intake and PLCE1 rs2274223 polymorphisms on esophageal squamous cell carcinoma risk.European journal of nutrition · 2021Article
- Lipid biomarkers and Cancer risk - a population-based prospective cohort study in Taiwan.Lipids in health and disease · 2021Article
- An impact of lipid profile and lipid lowering drugs on ≥70 year olds of an upper socioeconomic class: a retrospective cohort study.Lipids in health and disease · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background. Metabolic syndrome has been linked to an increased cancer risk, but the role of dyslipidaemia in gastrointestinal malignancies is unclear. We aimed to assess the risk of oesophageal, stomach, colon, and rectal cancers using serum levels of lipid components. Methods. From the Swedish Apolipoprotein Mortality Risk (AMORIS) study, we selected 540,309 participants (> 20 years old) with baseline measurements of total cholesterol (TC), triglycerides (TG), and glucose of whom 84,774 had baseline LDL cholesterol (LDL), HDL cholesterol (HDL), apolipoprotein B (apoB), and apolipoprotein A-I (apoA-I). Multivariate Cox proportional hazards regression was used to assess glucose and lipid components in relation to oesophageal, stomach, colon, and rectal cancer risk. Results. An increased risk of oesophageal cancer was observed in persons with high TG (e.g. HR: 2.29 (95% CI: 1.42-3.68) for the 4th quartile compared to the 1st) and low LDL, LDL/HDL ratio, TC/HDL ratio, log (TG/HDL), and apoB/apoA-I ratio. High glucose and TG were linked with an increased colon cancer risk, while high TC levels were associated with an increased rectal cancer risk. Conclusion. The persistent link between TC and rectal cancer risk as well as between TG and oesophageal and colon cancer risk in normoglycaemic individuals may imply their substantiality in gastrointestinal carcinogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.