ArticleFrontiers in physiology2012
Heart rate variability changes at 2400 m altitude predicts acute mountain sickness on further ascent at 3000-4300 m altitudes.
Article in Frontiers in physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 4 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Pooled it
- Effects of acute high-altitude exposure on heart rate variability: a systematic review and meta-analysis.Frontiers in physiology · 2025Pooled it
- Pulse oximetry for the prediction of acute mountain sickness: A systematic review.Experimental physiology · 2024Pooled it
- Association between acute mountain sickness (AMS) and age: a meta-analysis.Military Medical Research · 2018Pooled it
- Clustering analysis of acute mountain sickness susceptibility among young adults during rapid ascent using low-altitude step test data.Physiological reports · 2026Article
- Biomarkers and potential subtypes of acute mountain sickness: A state-of-the-science review.Redox biology · 2026Review
- A Novel Relationship between Corticotropin-Releasing Hormone Level and High-Altitude Hypoxia in Human and Rat Model.Neuroendocrinology · 2026Article
- Altitude-related variations in heart rate variability among native Sikkimese: A cross-sectional study.The Indian journal of medical research · 2025Article
- Closing the loop: autonomous intelligent control for hypoxia pre-acclimatization and high-altitude health management.National science review · 2025Review
- Sex differences in cardiorespiratory control under hypoxia: the roles of oxygen desaturation and hypoxic exposure time.Frontiers in cardiovascular medicine · 2025Article
- Acute high-altitude illness: risk factors, susceptibility prediction, and personalized prevention and treatment.Frontiers in medicine · 2025Review
- Investigating Sea-Level Brain Predictors for Acute Mountain Sickness: A Multimodal MRI Study before and after High-Altitude Exposure.AJNR. American journal of neuroradiology · 2024Article
- Dose-effect of exercise intervention on heart rate variability of acclimatized young male lowlanders at 3,680 m.Frontiers in physiology · 2024Article
- Association between high cardiac output at altitude and acute mountain sickness: preliminary study on Mt. Fuji.Journal of physiological anthropology · 2023Article
- Night-Time Heart Rate Variability during an Expedition to Mt Everest: A Case Report.Sports (Basel, Switzerland) · 2023Article
- Using machine learning to determine the correlation between physiological and environmental parameters and the induction of acute mountain sickness.BMC bioinformatics · 2022Article
- Contribution of Hypoxic Exercise Testing to Predict High-Altitude Pathology: A Systematic Review.Life (Basel, Switzerland) · 2022Review
- The Effect of High-Altitude Acclimatisation on Ultra-Short Heart Rate Variability.Frontiers in cardiovascular medicine · 2022Article
- Association between physiological responses after exercise at low altitude and acute mountain sickness upon ascent is sex-dependent.Military Medical Research · 2020Article
- Post-Exercise Recovery of Ultra-Short-Term Heart Rate Variability after Yo-Yo Intermittent Recovery Test and Repeated Sprint Ability Test.International journal of environmental research and public health · 2020Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIf the body fails to acclimatize at high altitude, acute mountain sickness (AMS) may result. For the early detection of AMS, changes in cardiac autonomic function measured by heart rate variability (HRV) may be more sensitive than clinical symptoms alone. The purpose of this study was to ascertain if the changes in HRV during ascent are related to AMS.
methodsWe followed Lake Louise Score (LLS), arterial oxygen saturation at rest (R-SpO(2)) and exercise (Ex-SpO(2)) and HRV parameters daily in 36 different healthy climbers ascending from 2400 m to 6300 m altitudes during five different expeditions.
resultsAfter an ascent to 2400 m, root mean square successive differences, high-frequency power (HF(2 min)) of HRV were 17-51% and Ex-SpO(2) was 3% lower in those climbers who suffered from AMS at 3000 to 4300 m than in those only developing AMS later (≥5000 m) or not at all (all p < 0.01). At the altitude of 2400 m RMSSD(2 min) ≤ 30 ms and Ex-SpO(2) ≤ 91% both had 92% sensitivity for AMS if ascent continued without extra acclimatization days.
conclusionsChanges in supine HRV parameters at 2400 m were related to AMS at 3000-4300 m Thus, analyses of HRV could offer potential markers for identifying the climbers at risk for AMS.
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