ArticleFrontiers in neural circuits2012
Direction selectivity in the larval zebrafish tectum is mediated by asymmetric inhibition.
Article in Frontiers in neural circuits, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 48 citations in OpenAlex.
- Decreased GABA levels during development result in increased connectivity in the larval zebrafish tectum.bioRxiv : the preprint server for biology · 2024Article
- From perception to behavior: The neural circuits underlying prey hunting in larval zebrafish.Frontiers in neural circuits · 2023Review
- Article
- Brain-Wide Mapping of Water Flow Perception in Zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Neural circuits for evidence accumulation and decision making in larval zebrafish.Nature neuroscience · 2020Article
- Optic tectal superficial interneurons detect motion in larval zebrafish.Protein & cell · 2019Article
- Updated functional segregation of retinal ganglion cell projections in the tectum of a cyprinid fish-further elaboration based on microelectrode recordings.Fish physiology and biochemistry · 2019Article
- Probabilistic Encoding Models for Multivariate Neural Data.Frontiers in neural circuits · 2019Review
- Synaptic Effects of Dopamine Breakdown and Their Relation to Schizophrenia-Linked Working Memory Deficits.Frontiers in synaptic neuroscience · 2018Article
- A Three-Layer Network Model of Direction Selective Circuits in the Optic Tectum.Frontiers in neural circuits · 2017Article
- Sustained Rhythmic Brain Activity Underlies Visual Motion Perception in Zebrafish.Cell reports · 2016Article
- Characterisation of sensitivity and orientation tuning for visually responsive ensembles in the zebrafish tectum.Scientific reports · 2016Article
- Article
- Article
- A Preliminary Study of the Effects of SurAsleep on Relieving Symptoms of Sleep Disorders.International journal of biomedical science : IJBS · 2015Article
- Neurons in the most superficial lamina of the mouse superior colliculus are highly selective for stimulus direction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Visuomotor transformations underlying hunting behavior in zebrafish.Current biology : CB · 2015Article
- Mapping brain activity at scale with cluster computing.Nature methods · 2014Article
- Retinal ganglion cell maps in the brain: implications for visual processing.Current opinion in neurobiology · 2014Review
- A systems-based dissection of retinal inputs to the zebrafish tectum reveals different rules for different functional classes during development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
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2 authors at 1 institution in 1 country.
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Abstract
The extraction of the direction of motion is an important computation performed by many sensory systems and in particular, the mechanism by which direction-selective retinal ganglion cells (DS-RGCs) in the retina acquire their selective properties, has been studied extensively. However, whether DS-RGCs simply relay this information to downstream areas or whether additional and potentially de novo processing occurs in these recipient structures is a matter of great interest. Neurons in the larval zebrafish tectum, the largest retino-recipent area in this animal, show direction-selective (DS) responses to moving visual stimuli but how these properties are acquired is still unknown. In order to study this, we first used two-photon calcium imaging to classify the population responses of tectal cells to bars moving at different speeds and in different directions. Subsequently, we performed in vivo whole cell electrophysiology on these DS tectal neurons and we found that their inhibitory inputs were strongly biased toward the null direction of motion, whereas the excitatory inputs showed little selectivity. In addition, we found that excitatory currents evoked by a stimulus moving in the preferred direction occurred before the inhibitory currents whereas a stimulus moving in the null direction evoked currents in the reverse temporal order. The membrane potential modulations resulting from these currents were enhanced by the spike generation mechanism to generate amplified direction selectivity in the spike output. Thus, our results implicate a local inhibitory circuit in generating direction selectivity in tectal neurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.