ReviewPLoS pathogens2012
Insights from genomics into bacterial pathogen populations.
Review in PLoS pathogens, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Interpreting whole genome sequencing for investigating tuberculosis transmission: a systematic review.BMC medicine · 2016Pooled it
- Coalescent inference for infectious disease: meta-analysis of hepatitis C.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Pooled it
- Analysis of soft rotFrontiers in microbiology · 2024Article
- Influence of Streptococcus pneumoniae Within-Strain Population Diversity on Virulence and Pathogenesis.Microbiology spectrum · 2023Article
- Article
- Enteric Pathogens Risk Factors Associated with Household Drinking Water: A Case Study in Ugu District Kwa-Zulu Natal Province, South Africa.International journal of environmental research and public health · 2022Article
- Cross-species RNA-seq for deciphering host-microbe interactions.Nature reviews. Genetics · 2021Review
- Clonal evolution ofJournal of oral microbiology · 2021Article
- Article
- Phylogenetic Methods for Genome-Wide Association Studies in Bacteria.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Frequency of Antimicrobial Resistance Genes inFrontiers in microbiology · 2020Article
- Targeting ADP-ribosylation as an antimicrobial strategy.Biochemical pharmacology · 2019Review
- Clonal yet Different: Understanding the Causes of Genomic Heterogeneity in Microbial Species and Impacts on Public Health.mSystems · 2019Article
- Comparative Genomic Analysis ofFrontiers in microbiology · 2019Article
- Bayesian reconstruction of transmission within outbreaks using genomic variants.PLoS computational biology · 2018Article
- Comparative Analysis of Genomic Island Prediction Tools.Frontiers in genetics · 2018Article
- Variability in metagenomic samples from the Puget Sound: Relationship to temporal and anthropogenic impacts.PloS one · 2018Article
- Vibrio cholerae genomic diversity within and between patients.Microbial genomics · 2017Article
- The Bacterial Sequential Markov Coalescent.Genetics · 2017Article
- Small Molecules That Sabotage Bacterial Virulence.Trends in pharmacological sciences · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Bacterial pathogens impose a heavy burden of disease on human populations worldwide. The gravest threats are posed by highly virulent respiratory pathogens, enteric pathogens, and HIV-associated infections. Tuberculosis alone is responsible for the deaths of 1.5 million people annually. Treatment options for bacterial pathogens are being steadily eroded by the evolution and spread of drug resistance. However, population-level whole genome sequencing offers new hope in the fight against pathogenic bacteria. By providing insights into bacterial evolution and disease etiology, these approaches pave the way for novel interventions and therapeutic targets. Sequencing populations of bacteria across the whole genome provides unprecedented resolution to investigate (i) within-host evolution, (ii) transmission history, and (iii) population structure. Moreover, advances in rapid benchtop sequencing herald a new era of real-time genomics in which sequencing and analysis can be deployed within hours in response to rapidly changing public health emergencies. The purpose of this review is to highlight the transformative effect of population genomics on bacteriology, and to consider the prospects for answering abiding questions such as why bacteria cause disease.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.