ArticleInternational journal of nanomedicine2012
Dual drug delivery system for targeting H. pylori in the stomach: preparation and in vitro characterization of amoxicillin-loaded Carbopol® nanospheres.
Article in International journal of nanomedicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Application of Nanodrug Delivery Systems in Enhancing Treatment of Gastritis and Gastric Cancer: A Systematic Evaluation of Targeted Therapy.Pharmaceutics · 2025Review
- Treatment ofHeliyon · 2023Review
- Review
- Amoxicillin and Clarithromycin Mucoadhesive Delivery System forPharmaceutics · 2021Article
- HPMC- and PLGA-Based Nanoparticles for the Mucoadhesive Delivery of Sitagliptin: Optimization and In Vivo Evaluation in Rats.Materials (Basel, Switzerland) · 2019Article
- An Efficient, Lung-Targeted, Drug-Delivery System To Treat Asthma Via Microparticles.Drug design, development and therapy · 2019Article
- Chemotherapeutic drug targeting to lungs by way of microspheres after intravenous administration.Drug design, development and therapy · 2018Article
- Nanoparticle formulation by Büchi B-90 Nano Spray Dryer for oral mucoadhesion.Drug design, development and therapy · 2015Article
- Pharmaceutical suspension containing both immediate/sustained-release amoxicillin-loaded gelatin nanoparticles: preparation and in vitro characterization.Drug design, development and therapy · 2013Article
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1 author.
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Abstract
BACKGROUND AND
methodsA dual (immediate/sustained-release) oral amoxicillin suspension was developed as a new dosage form to eradicate Helicobacter pylori. Carbopol®-loaded amoxicillin nanospheres could bind with the mucosa after delivery to the stomach and could increase the efficiency of the drug, providing both an immediate and a sustained action.
resultsThe objective of this research was to develop amoxicillin nanospheres using a spray-drying technique and to investigate such features as their particle size, drug content, percentage yield, surface morphology, in vitro release, and stability. The nanospheres had a particle size range of 280-320 nm after optimizing the preparation method using a central composite design. The drug content and percentage yield was 85.3% ± 0.7% and 92.8% ± 0.9%, respectively. The in vitro release profile of the amoxicillin nanospheres was consistent with a Korsmeyer-Peppas pattern, and the release after one hour was 19%, while for the original drug, amoxicillin, under the same conditions, 90% was released in the first 30 minutes.
conclusionThe nanospheres used in this study enabled controlled release of amoxicillin over an extended period of time for up to 12 hours and the formulation was stable for 12 months.
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