ArticleJournal of Korean medical science2012
Ceftiaxone-induced neurotoxicity: case report, pharmacokinetic considerations, and literature review.
Article in Journal of Korean medical science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Neurological Adverse Effects Attributable to β-Lactam Antibiotics: A Literature Review.Drug safety · 2017Pooled it
- Ceftriaxone encephalopathy in a very elderly dialysis patient.CEN case reports · 2025Article
- The Assessment and Efficiency of Cefixime in Upper Respiratory Tract Infections: Insights and Perspectives.Cureus · 2024Review
- Article
- Ceftriaxone-induced encephalopathy in a patient with a normal renal function.BMJ case reports · 2024Article
- Non-convulsive status epilepticus possibly induced by a rapid correction of severe hyperkalemia: a case report and literature review.BMC nephrology · 2023Review
- Physiologically-based pharmacokinetic modeling for single and multiple dosing regimens of ceftriaxone in healthy and chronic kidney disease populations: a tool for model-informed precision dosing.Frontiers in pharmacology · 2023Article
- Importance and Reality of TDM for Antibiotics Not Covered by Insurance in Japan.International journal of environmental research and public health · 2022Review
- Ceftriaxone-induced encephalopathy in a patient with multicentric glioma.Surgical neurology international · 2022Article
- Serious Neurological Adverse Events of Ceftriaxone.Antibiotics (Basel, Switzerland) · 2021Article
- Involuntary Movements Following Administration of Hydroxychloroquine for COVID-19 Pneumonia.Journal of movement disorders · 2021Article
- Ceftriaxone-induced Encephalopathy: A Pharmacokinetic Approach.European journal of case reports in internal medicine · 2021Article
- Infectious stress triggers a POLG-related mitochondrial disease.Neurogenetics · 2020Article
- Reversible Choreoathetosis in a Patient with End-stage Renal Disease from Administration of Ceftriaxone.Cureus · 2019Article
- Encephalopathy Induced by High Plasma and Cerebrospinal Fluid Ceftriaxone Concentrations in a Hemodialysis Patient.Internal medicine (Tokyo, Japan) · 2019Article
- Commentary on "Beta-Lactam Antibiotics as A Possible Novel Therapy for Managing Epilepsy and Autism.Iranian journal of child neurology · 2018Article
- Ceftriaxone-induced Neurotoxicity in a Patient after Pancreas-Kidney Transplantation.Internal medicine (Tokyo, Japan) · 2017Article
- Three Cases of Hemodialysis Patients Receiving High-Dose Ceftriaxone: Serum Concentrations and Its Neurotoxicity.Kidney international reports · 2017Article
- A fatal adverse effect of cefazolin administration: severe brain edema in a patient with multiple meningiomas.Drug, healthcare and patient safety · 2016Article
- Nonconvulsive status epilepticus cases arising in connection with cephalosporins.Epilepsy & behavior case reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ceftriaxone is widely used in patients for the treatment of serious gram-negative infections. Ceftriaxone can induce some potential side effects, including neurotoxicity, however, nonconvulsive status epilepticus has rarely been reported. We report a case of acute reversible neurotoxicity associated with ceftriaxone. A 65-yr-old woman with chronic kidney disease developed altered consciousness during ceftriaxone treatment for urinary tract infection. The electroencephalogram demonstrated continuous bursts of generalized, high-voltage, 1 to 2 Hz sharp wave activity. Neurologic symptoms disappeared following withdrawal of ceftriaxone. The possibility of ceftriaxone-induced neurotoxicity should be considered in patients developing neurological impairment during ceftriaxone use, and the discontinuation of the drug could lead to complete neurological improvement.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.