ArticleThe Journal of clinical endocrinology and metabolism2012
Endothelial function is impaired across the stages of the menopause transition in healthy women.
Article in The Journal of clinical endocrinology and metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 169 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Biological Mechanisms of Arterial Stiffening With Age and Estrogen Deficiency
Mechanisms of Vascular Dysfunction in Women: Role of Estradiol
Who cites it
169 citing papers in PubMed, 8 syntheses or guidelines pooled it, 324 citations in OpenAlex.
- Effects of Citrulline Malate Supplementation on Exercise Performance: A Systematic Review and Three-Level Meta-Analysis.Nutrients · 2026Pooled it
- Impacts of Physical Inactivity Models on Endothelial Function: A Systematic Review.Sports medicine (Auckland, N.Z.) · 2025Pooled it
- Effectiveness of exercise training on arterial stiffness and blood pressure among postmenopausal women: a systematic review and meta-analysis.Systematic reviews · 2024Pooled it
- Menstrual cycle hormones and oral contraceptives: a multimethod systems physiology-based review of their impact on key aspects of female physiology.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Pooled it
- Effect of Exercise on Vascular Function and Blood Lipids in Postmenopausal Women: A Systematic Review and Network Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Examination of Sex-Specific Participant Inclusion in Exercise Physiology Endothelial Function Research: A Systematic Review.Frontiers in sports and active living · 2022Pooled it
- Effects of Different Intensities and Durations of Aerobic Exercise on Vascular Endothelial Function in Middle-Aged and Elderly People: A Meta-analysis.Frontiers in physiology · 2021Pooled it
- Does Gender Influence the Relationship Between High Blood Pressure and Dementia? Highlighting Areas for Further Investigation.Journal of Alzheimer's disease : JAD · 2020Pooled it
- The acute effect of two exercise modalities on neurocognitive responses in postmenopausal women: A randomized controlled trial.Experimental physiology · 2026Trial
- The Impact of Cocoa Flavanols in Modulating Resting Cerebral Blood Flow During Prolonged Sitting in Healthy Young and Older Adults.Nutrients · 2025Trial
- Impact of a Precision Intervention for Vascular Health in Middle-Aged and Older Postmenopausal Women Using Polar Heart Rate Sensors: A 24-Week RCT Study Based on the New Compilation of Tai Chi (Bafa Wubu).Sensors (Basel, Switzerland) · 2024Trial
- L-Citrulline Supplementation Improves Arterial Blood Flow and Muscle Oxygenation during Handgrip Exercise in Hypertensive Postmenopausal Women.Nutrients · 2024Trial
- Combined Citrulline and Glutathione Supplementation Improves Endothelial Function and Blood Pressure Reactivity in Postmenopausal Women.Nutrients · 2023Trial
- The effect of exercise training on endothelial function in postmenopausal women with breast cancer under aromatase inhibitor therapy.Cancer medicine · 2022Trial
- Effects of L-Citrulline Supplementation on Endothelial Function and Blood Pressure in Hypertensive Postmenopausal Women.Nutrients · 2022Trial
- Oxidative Stress and Inflammation Are Associated With Age-Related Endothelial Dysfunction in Men With Low Testosterone.The Journal of clinical endocrinology and metabolism · 2022Trial
- Sex differences in endothelial function in chronic kidney disease.American journal of physiology. Renal physiology · 2020Trial
- Effects of resveratrol or estradiol on postexercise endothelial function in estrogen-deficient postmenopausal women.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Trial
- Impact of low-intensity resistance and whole-body vibration training on aortic hemodynamics and vascular function in postmenopausal women.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Trial
- Cardiac Adaptations to High-Intensity Aerobic Training in Premenopausal and Recent Postmenopausal Women: The Copenhagen Women Study.Journal of the American Heart Association · 2017Trial
109 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
contextThe stages of the menopause transition are characterized by changes in ovarian hormones and increased cardiovascular disease (CVD) risk factors and vasomotor symptoms that may adversely affect vascular health.
objectiveWe tested the hypothesis that endothelial function, a predictor of CVD, would be reduced across the stages of the menopause transition, independent of CVD risk factors and vasomotor symptoms. DESIGN, SETTING, AND
participantsThis was a cross-sectional study of 132 healthy women from the general community aged 22-70 yr, categorized as premenopausal (n = 33, 32 ± 6 yr; mean ± SD), early perimenopausal (n = 20, 49 ± 3 yr) or late perimenopausal (n = 22, 50 ± 4 yr), or early (n = 30, 55 ± 3 yr) or late postmenopausal (n = 27, 61 ± 4 yr). MAIN OUTCOME: Endothelial-dependent vasodilation was measured by brachial artery flow-mediated dilation (FMD) using ultrasound.
resultsBrachial artery FMD was significantly different among the groups (P < 0.001). It was highest in premenopausal women (9.9 ± 2.1%) with progressive decrements in perimenopausal (early: 8.2 ± 2.5%; late: 6.5 ± 1.9%) and postmenopausal women (early: 5.5 ± 1.9%; late: 4.7 ± 1.7%). Adjustment for risk factors, vasomotor symptoms, and sex hormones did not alter the association (P < 0.001). In subgroup analyses of women aged 50-59 yr, brachial artery FMD was lower in late peri- and early and late postmenopausal compared with early perimenopausal women (P < 0.001) but was not different between late perimenopausal and either early or late postmenopausal women.
conclusionsOur findings suggest that a decline in endothelial function begins during the early stages of menopause (perimenopause) and worsens with the loss of ovarian function and prolonged estrogen deficiency. These data add to the accumulating evidence that the perimenopausal window is a critical time period for adverse changes in CVD risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.