ArticleGenetic epidemiology2012
SNP set association analysis for familial data.
Article in Genetic epidemiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 1 of them a synthesis that pooled it.
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Who cites it
76 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Methods for association analysis and meta-analysis of rare variants in families.Genetic epidemiology · 2015Pooled it
- Gene-based association tests in family samples using GWAS summary statistics.Genetic epidemiology · 2024Article
- Article
- A novel rare variants association test for binary traits in family-based designs via copulas.Statistical methods in medical research · 2023Article
- Simultaneous selection of multiple important single nucleotide polymorphisms in familial genome wide association studies data.Scientific reports · 2023Article
- An Efficient Bayesian Method for Estimating the Degree of the Skewness of X Chromosome Inactivation Based on the Mixture of General Pedigrees and Unrelated Females.Biomolecules · 2023Article
- How can childhood maltreatment affect post-traumatic stress disorder in adult: Results from a composite null hypothesis perspective of mediation analysis.Frontiers in psychiatry · 2023Article
- Dissecting Complex Traits Using Omics Data: A Review on the Linear Mixed Models and Their Application in GWAS.Plants (Basel, Switzerland) · 2022Review
- A comprehensive comparison of multilocus association methods with summary statistics in genome-wide association studies.BMC bioinformatics · 2022Article
- Gene Region Association Analysis of Longitudinal Quantitative Traits Based on a Function-On-Function Regression Model.Frontiers in genetics · 2022Article
- Recent advances and challenges of rare variant association analysis in the biobank sequencing era.Frontiers in genetics · 2022Review
- A comprehensive gene-centric pleiotropic association analysis for 14 psychiatric disorders with GWAS summary statistics.BMC medicine · 2021Article
- Integrative eQTL-weighted hierarchical Cox models for SNP-set based time-to-event association studies.Journal of translational medicine · 2021Article
- Family-based gene-environment interaction using sequence kernel association test (FGE-SKAT) for complex quantitative traits.Scientific reports · 2021Article
- Identification of QTL regions and candidate genes for growth and feed efficiency in broilers.Genetics, selection, evolution : GSE · 2021Article
- Detection of Genetic Overlap Between Rheumatoid Arthritis and Systemic Lupus Erythematosus Using GWAS Summary Statistics.Frontiers in genetics · 2021Article
- Rare Coding Variants Associated with Breast Cancer.Advances in experimental medicine and biology · 2021Article
- RAINBOW: Haplotype-based genome-wide association study using a novel SNP-set method.PLoS computational biology · 2020Article
- A review of kernel methods for genetic association studies.Genetic epidemiology · 2019Review
- Linear mixed models for association analysis of quantitative traits with next-generation sequencing data.Genetic epidemiology · 2019Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Genome-wide association studies (GWAS) are a popular approach for identifying common genetic variants and epistatic effects associated with a disease phenotype. The traditional statistical analysis of such GWAS attempts to assess the association between each individual single-nucleotide polymorphism (SNP) and the observed phenotype. Recently, kernel machine-based tests for association between a SNP set (e.g., SNPs in a gene) and the disease phenotype have been proposed as a useful alternative to the traditional individual-SNP approach, and allow for flexible modeling of the potentially complicated joint SNP effects in a SNP set while adjusting for covariates. We extend the kernel machine framework to accommodate related subjects from multiple independent families, and provide a score-based variance component test for assessing the association of a given SNP set with a continuous phenotype, while adjusting for additional covariates and accounting for within-family correlation. We illustrate the proposed method using simulation studies and an application to genetic data from the Genetic Epidemiology Network of Arteriopathy (GENOA) study.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.