ArticleEuropean radiology2013
Differential NMR spectroscopy reactions of anterior/posterior and right/left insular subdivisions due to acute dental pain.
Article in European radiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Functional MRS studies of GABA and glutamate/Glx - A systematic review and meta-analysis.Neuroscience and biobehavioral reviews · 2023Pooled it
- Neurometabolic signatures of gastrointestinal symptoms in the insula of Crohn's disease patients: explorative findings from a 7T MRS study.Frontiers in human neuroscience · 2025Article
- Neurochemical dynamics during two hypnotic states evidenced by magnetic resonance spectroscopy.Scientific reports · 2024Article
- Testing PET-[Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Event-related functional magnetic resonance spectroscopy.NeuroImage · 2023Review
- A Critical Involvement of Glutamatergic Neurons in the Anterior Insular Cortex for Subdiaphragmatic Vagotomy-induced Analgesia.Experimental neurobiology · 2023Article
- Article
- Human brain functional MRS reveals interplay of metabolites implicated in neurotransmission and neuroenergetics.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Metabolite activity in the anterior cingulate cortex during a painful stimulus using functional MRS.Scientific reports · 2020Article
- Altered thalamic neurotransmitters metabolism and functional connectivity during the development of chronic constriction injury induced neuropathic pain.Biological research · 2020Article
- Reproducibility of Neurochemical Profile Quantification in Pregenual Cingulate, Anterior Midcingulate, and Bilateral Posterior Insular Subdivisions Measured at 3 Tesla.Frontiers in human neuroscience · 2016Article
- Cingulate metabolites during pain and morphine treatment as assessed by magnetic resonance spectroscopy.Journal of pain research · 2014Article
- Does the brain's E:I balance really shape long-range temporal correlations? Lessons learned from 3T MRI.Imaging neuroscience (Cambridge, Mass.)Article
- The PKCγ neurons in anterior cingulate cortex contribute to the development of neuropathic allodynia and pain-related emotion.Molecular painArticle
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe insular cortex has an important role within the cerebral pain circuitry. The aim of this study was to measure metabolic alterations by MR spectroscopy due to experimentally induced trigeminal pain in the anterior/posterior and right/left insular subdivisions.
methodsSixteen male volunteers were investigated using magnetic resonance (MR) spectroscopy before, during and after experimentally induced dental pain. Biphasic bipolar electric current pulses of 1 ms duration were administered based on the subjectively determined pain threshold. Volunteers were instructed to rate every stimulus using a MR compatible rating scale.
resultsDue to the pain stimulation a significant absolute increase in glutamate (Glu, F = 6.1; P = 0.001), glutamine (Gln, F = 11.2; P = 0.001) as well as glutamate/glutamine (Glx, F = 17.7; P = 0.001) were observed, whereas myo-inositol (mI, F = 9.5;P = 0.001) showed a significant drop. Additionally, these metabolites showed a significant effect towards lateralisation, meaning that metabolic concentration differed either in left or right insular subdivision. Creatine demonstrated also an absolute significant decrease during stimulation (F = 2.8; P = 0.022) with a significant anterior-posterior difference (F = 40.7; P = 0.001).
conclusionsResults confirm that the insular cortex is a metabolically high active region in pain processing within the brain. Quantitative metabolic changes show that there is a distinct but locally diverse neurometabolic activity under acute pain. The known cytoarchitectonic subdivisions show different metabolic reactions and give new insights into pain-processing physiology.
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