Evidence map›Paper›PMID 22968708›Full record

ReviewImmunologic research2013

Pulmonary dendritic cell development and antigen acquisition.

A Nicole Desch, Peter M Henson, Claudia V Jakubzick

Abstract readReview
In one paragraph

Review in Immunologic research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. [Pulmonary innate immune response in Sars-cov-2 infection]Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) · 2022
    Pooled it
  2. Review
  3. Review
  4. Nanoparticle-Based Pulmonary Immune Engineering.Annual review of chemical and biomolecular engineering · 2025
    Review
  5. Heat-KilledFoods (Basel, Switzerland) · 2023
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Host Response toFrontiers in cellular and infection microbiology · 2020
    Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

A Nicole DeschIntegrated Department of Immunology, University of Colorado School of Medicine, Denver, CO, USA.
Peter M Henson
Claudia V Jakubzick

Funding

Regulation of Pulmonary InflammationR01HL081151 · NHLBI · NATIONAL JEWISH HEALTH · PI HENSON, PETER M · 2005 to 2012
$3.5M
Apoptosis and defective repair in COPDR01HL088138 · NHLBI · NATIONAL JEWISH HEALTH · PI HENSON, PETER M · 2008 to 2012
$3.5M
Understanding the unique role endogenous APC subtypes play during the rejection of MAg-mismatched cellsR01HL115334 · NHLBI · NATIONAL JEWISH HEALTH · PI JAKUBZICK, CLAUDIA V · 2013 to 2020
$3.3M
REGULATION OF INFLAMMATION BY PULMONARY COLLECTINSR01HL068864 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI HENSON, PETER M · 2002 to 2012
$3.3M
NHLBI NIH HHS HL68864NHLBI NIH HHS HL81151NHLBI NIH HHS HL88138NHLBI NIH HHS R01 HL068864NHLBI NIH HHS R01 HL088138NHLBI NIH HHS R01 HL115334PHS HHS T32-A107045
6 · The paper itself

Abstract

Pulmonary dendritic cells (DCs) constantly sample the tissue and traffic inhaled antigens to the lung-draining lymph node where they normally orchestrate an appropriate immune response. The dynamic ability of these professional antigen-presenting cells to promote tolerance or immunity has been intensively studied by several groups, including ours. Distinct DC subsets in both lymphoid and non-lymphoid tissues have been described based on their surface molecule expression and location. Current efforts to unravel DC development and function are providing insight into the various roles each subset offers the immune system. Elucidating DC functions, particularly in the lung, may then allow use of the inherent ability of these cells for enhanced vaccine strategies and therapeutics for pulmonary infections and diseases.

Indexed as

AnimalsAntigen PresentationAntigensDendritic CellsLungProtein TransportAntigens

Identifiers

PMID22968708
PMCPMC4153344

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.