ArticleMetabolic brain disease2012
Methylphenidate induces lipid and protein damage in prefrontal cortex, but not in cerebellum, striatum and hippocampus of juvenile rats.
Article in Metabolic brain disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 50 citations in OpenAlex.
- The effect of methylphenidate intake on brain structure in adults with ADHD in a placebo-controlled randomized trial.Journal of psychiatry & neuroscience : JPN · 2016Trial
- Salivary gland function and redox status in young adult male rats treated with the psychostimulant short-release methylphenidate.Odontology · 2026Article
- Ameliorative Effects of High-Intensity Interval Training (HIIT) and Methylphenidate Against Tramadol-Induced Cognitive Impairment: The Role of Hippocampal Oxidative Stress.Brain and behavior · 2025Article
- Novel hematologic ratios and systemic inflammation index in ADHD: effects of methylphenidate treatment.Frontiers in psychiatry · 2025Article
- Investigating the Impact of Nutrition and Oxidative Stress on Attention Deficit Hyperactivity Disorder.Nutrients · 2024Review
- Methylphenidate Exposing During Neurodevelopment Alters Amino Acid Profile, Astrocyte Marker and Glutamatergic Excitotoxicity in the Rat Striatum.Neurotoxicity research · 2024Article
- Changes in Cortisol and in Oxidative/Nitrosative Stress Indicators after ADHD Treatment.Antioxidants (Basel, Switzerland) · 2024Article
- Age-related changes in the architecture and biochemical markers levels in motor-related cortical areas of SHR rats-an ADHD animal model.Frontiers in molecular neuroscience · 2024Article
- Atomoxetine Decreases Mitochondrial Biogenesis, Fission and Fusion In Human Neuron-like Cells But Does Not Alter Antioxidant Defences.Cell biochemistry and biophysics · 2023Article
- Association Between ADHD and COVID-19 Infection and Clinical Outcomes: A Retrospective Cohort Study From Electronic Medical Records.Journal of attention disorders · 2023Article
- Oxidative Stress and Psychiatric Disorders: Evidence from the Bidirectional Mendelian Randomization Study.Antioxidants (Basel, Switzerland) · 2022Article
- Evidence That Methylphenidate Treatment Evokes Anxiety-Like Behavior Through Glucose Hypometabolism and Disruption of the Orbitofrontal Cortex Metabolic Networks.Neurotoxicity research · 2021Article
- Role of Oxidative Stress and Neuroinflammation in Attention-Deficit/Hyperactivity Disorder.Antioxidants (Basel, Switzerland) · 2020Review
- Methylphenidate disrupts cytoskeletal homeostasis and reduces membrane-associated lipid content in juvenile rat hippocampus.Metabolic brain disease · 2018Article
- Methylphenidate Decreases ATP Levels and Impairs Glutamate Uptake and NaMolecular neurobiology · 2017Article
- Methylphenidate Causes Behavioral Impairments and Neuron and Astrocyte Loss in the Hippocampus of Juvenile Rats.Molecular neurobiology · 2017Article
- Effects of acute doses of methylphenidate on inflammation and oxidative stress in isolated hippocampus and cerebral cortex of adult rats.Journal of neural transmission (Vienna, Austria : 1996) · 2017Article
- Chronic Treatment with a Clinically Relevant Dose of Methylphenidate Increases Glutamate Levels in Cerebrospinal Fluid and Impairs Glutamatergic Homeostasis in Prefrontal Cortex of Juvenile Rats.Molecular neurobiology · 2016Article
- ToF-SIMS imaging of lipids and lipid related compounds in Drosophila brain.Surface and interface analysis : SIA · 2014Article
- Effects of 900-MHz radiation on the hippocampus and cerebellum of adult rats and attenuation of such effects by folic acid andJournal of microscopy and ultrastructureArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of psychostimulant methylphenidate has increased in recent years for the treatment of attention-deficit hyperactivity disorder in children and adolescents. However, the behavioral and neurochemical changes promoted by its use are not yet fully understood, particularly when used for a prolonged period during stages of brain development. Thus, the aim of this study was to determine some parameters of oxidative stress in encephalic structures of juvenile rats subjected to chronic methylphenidate treatment. Wistar rats received intraperitoneal injections of methylphenidate (2.0 mg/kg) once a day, from the 15th to the 45th day of age or an equivalent volume of 0.9% saline solution (controls). Two hours after the last injection, animals were euthanized and the encephalic structures obtained for determination of oxidative stress parameters. Results showed that methylphenidate administration increased the activities of superoxide dismutase and catalase, but did not alter the levels of reactive species, thiobarbituric acid reactive substances levels and sulfhydryl group in cerebellum of rats. In striatum and hippocampus, the methylphenidate-treated rats presented a decrease in the levels of reactive species and thiobarbituric acid reactive substances, but did not present changes in the sulfhydryl groups levels. In prefrontal cortex, methylphenidate promoted an increase in reactive species formation, SOD/CAT ratio, and increased the lipid peroxidation and protein damage. These findings suggest that the encephalic structures respond differently to methylphenidate treatment, at least, when administered chronically to young rats. Notably, the prefrontal cortex of juvenile rats showed greater sensitivity to oxidative effects promoted by methylphenidate in relation to other encephalic structures analyzed.
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