Evidence map›Paper›PMID 22968315›Full record

SynthesisCurrent atherosclerosis reports2012

Arsenic exposure and cardiovascular disease: an updated systematic review.

Katherine Moon, Eliseo Guallar, Ana Navas-Acien

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Current atherosclerosis reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 185 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
185citing papers in PubMed, 13 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

185 citing papers in PubMed, 13 syntheses or guidelines pooled it.

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125 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Katherine MoonDepartment of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Room W7604, Baltimore, MD 21205, USA. kmoon@jhsph.edu
Eliseo Guallar
Ana Navas-Acien

Funding

Arsenic Exposure, Cardiovascular Disease and Diabetes in Native AmericansR01HL090863 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI NAVAS-ACIEN, ANA · 2008 to 2011
$3.1M
Arsenic Exposure, Genetic Determinants and Diabetes Risk in a Family StudyR01ES021367 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI NAVAS-ACIEN, ANA, VAIDYA, DHANANJAY MADHUKAR · 2012 to 2015
$2.4M
NHLBI NIH HHS R01 HL090863NHLBI NIH HHS R01HL090863NIEHS NIH HHS R01 ES021367NIEHS NIH HHS R01ES021367
6 · The paper itself

Abstract

In epidemiologic studies, high-chronic arsenic exposure has been associated with cardiovascular disease, despite methodological limitations. At low-moderate arsenic levels, the evidence was inconclusive. Here, we update a previous systematic review (Am J Epidemiol 2005;162:1037-49) examining the association between arsenic exposure and cardiovascular disease. Eighteen studies published since 2005 were combined with 13 studies from the previous review. We calculated pooled relative risks by comparing the highest versus the lowest exposure category across studies. For high exposure (arsenic in drinking water > 50 μg/L), the pooled relative risks (95 % confidence interval) for cardiovascular disease, coronary heart disease, stroke, and peripheral arterial disease were 1.32 (95 % CI:1.05-1.67), 1.89 (95 % CI:1.33-2.69), 1.08 (95 % CI:0.98-1.19), and 2.17 (95 % CI:1.47-3.20), respectively. At low-moderate arsenic levels, the evidence was inconclusive. Our review strengthens the evidence for a causal association between high-chronic arsenic exposure and clinical cardiovascular endpoints. Additional high quality studies are needed at low-moderate arsenic levels.

Indexed as

ArsenicCardiovascular DiseasesEnvironmental ExposureEpidemiologic StudiesHumansIncidenceRiskArsenic

Identifiers

PMID22968315
PMCPMC3483370

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.