ArticlePhysics in medicine and biology2012
MARS: a mouse atlas registration system based on a planar x-ray projector and an optical camera.
Article in Physics in medicine and biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Small animal PET: a review of what we have done and where we are going.Physics in medicine and biology · 2020Review
- Imaging of Mouse Brain Fixated in Ethanol in Micro-CT.BioMed research international · 2019Article
- Automated quantification of bioluminescence images.Nature communications · 2018Article
- Estimation of subject coregistration errors during multimodal preclinical imaging using separate instruments: origins and avoidance of artifacts.Journal of medical imaging (Bellingham, Wash.) · 2017Article
- Canny edge-based deformable image registration.Physics in medicine and biology · 2017Article
- A deformable atlas of the laboratory mouse.Molecular imaging and biology · 2015Article
- Optimization of the Energy Window for PETbox4, a Preclinical PET Tomograph With a Small Inner Diameter.IEEE transactions on nuclear science · 2014Article
- Individually ventilated cages impose cold stress on laboratory mice: a source of systemic experimental variability.Journal of the American Association for Laboratory Animal Science : JAALAS · 2013Article
- The hidden cost of housing practices: using noninvasive imaging to quantify the metabolic demands of chronic cold stress of laboratory mice.Comparative medicine · 2013Article
- Evaluation of the Genisys4, a bench-top preclinical PET scanner.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2013Article
- NEMA NU-4 performance evaluation of PETbox4, a high sensitivity dedicated PET preclinical tomograph.Physics in medicine and biology · 2013Article
- A method of 2D/3D registration of a statistical mouse atlas with a planar X-ray projection and an optical photo.Medical image analysis · 2013Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
This paper introduces a mouse atlas registration system (MARS), composed of a stationary top-view x-ray projector and a side-view optical camera, coupled to a mouse atlas registration algorithm. This system uses the x-ray and optical images to guide a fully automatic co-registration of a mouse atlas with each subject, in order to provide anatomical reference for small animal molecular imaging systems such as positron emission tomography (PET). To facilitate the registration, a statistical atlas that accounts for inter-subject anatomical variations was constructed based on 83 organ-labeled mouse micro-computed tomography (CT) images. The statistical shape model and conditional Gaussian model techniques were used to register the atlas with the x-ray image and optical photo. The accuracy of the atlas registration was evaluated by comparing the registered atlas with the organ-labeled micro-CT images of the test subjects. The results showed excellent registration accuracy of the whole-body region, and good accuracy for the brain, liver, heart, lungs and kidneys. In its implementation, the MARS was integrated with a preclinical PET scanner to deliver combined PET/MARS imaging, and to facilitate atlas-assisted analysis of the preclinical PET images.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.