ArticleEuropean journal of human genetics : EJHG2013
Low-density lipoprotein receptor mutations generate synthetic genome-wide associations.
Article in European journal of human genetics : EJHG, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 7 citations in OpenAlex.
- The application of transcriptomic data in the authentication of beef derived from contrasting production systems.BMC genomics · 2016Article
- Progress in genetic association studies of plasma lipids.Current opinion in lipidology · 2013Review
- Causal and synthetic associations of variants in the SERPINA gene cluster with alpha1-antitrypsin serum levels.PLoS genetics · 2013Article
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13 authors at 2 institutions in 2 countries.
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Abstract
Genome-wide association (GWA) studies have discovered multiple common genetic risk variants related to common diseases. It has been proposed that a number of these signals of common polymorphisms are based on synthetic associations that are generated by rare causative variants. We investigated if mutations in the low-density lipoprotein receptor (LDLR) gene causing familial hypercholesterolemia (FH, OMIM #143890) produce such signals. We genotyped 480 254 polymorphisms in 464 FH patients and in 5945 subjects from the general population. A total of 28 polymorphisms located up to 2.4 Mb from the LDLR gene were genome-wide significantly associated with FH (P<10(-8)). We replicated the 10 top signals in 2189 patients with a clinical diagnosis of FH and in 2157 subjects of a second sample of the general population (P<0.000087). Our findings confirm that rare variants are able to cause synthetic genome-wide significant associations, and that they exert this effect at relatively large distances from the causal mutation.
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