ArticleNeural development2012
Ultrabithorax confers spatial identity in a context-specific manner in the Drosophila postembryonic ventral nervous system.
Article in Neural development, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Article
- The Hox Gene,Molecular biology of the cell · 2025Article
- The Hox Gene,bioRxiv : the preprint server for biology · 2025Article
- Cell-type-specific Hox regulatory strategies orchestrate tissue identity.Current biology : CB · 2021Article
- Article
- Article
- Control of tissue morphogenesis by the HOX geneDevelopment (Cambridge, England) · 2020Article
- A Single MicroRNA-Hox Gene Module Controls Equivalent Movements in Biomechanically Distinct Forms of Drosophila.Current biology : CB · 2019Article
- Article
- Article
- Article
- Neural stem cell progeny regulate stem cell death in a Notch and Hox dependent manner.Cell death and differentiation · 2015Article
- Bridging the gap between postembryonic cell lineages and identified embryonic neuroblasts in the ventral nerve cord of Drosophila melanogaster.Biology open · 2015Article
- Postembryonic lineages of the Drosophila brain: II. Identification of lineage projection patterns based on MARCM clones.Developmental biology · 2013Article
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9 authors.
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Abstract
backgroundIn holometabolous insects such as Drosophila melanogaster, neuroblasts produce an initial population of diverse neurons during embryogenesis and a much larger set of adult-specific neurons during larval life. In the ventral CNS, many of these secondary neuronal lineages differ significantly from one body segment to another, suggesting a role for anteroposterior patterning genes.
resultsHere we systematically characterize the expression pattern and function of the Hox gene Ultrabithorax (Ubx) in all 25 postembryonic lineages. We find that Ubx is expressed in a segment-, lineage-, and hemilineage-specific manner in the thoracic and anterior abdominal segments. When Ubx is removed from neuroblasts via mitotic recombination, neurons in these segments exhibit the morphologies and survival patterns of their anterior thoracic counterparts. Conversely, when Ubx is ectopically expressed in anterior thoracic segments, neurons exhibit complementary posterior transformation phenotypes.
conclusionOur findings demonstrate that Ubx plays a critical role in conferring segment-appropriate morphology and survival on individual neurons in the adult-specific ventral CNS. Moreover, while always conferring spatial identity in some sense, Ubx has been co-opted during evolution for distinct and even opposite functions in different neuronal hemilineages.
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