Evidence map›Paper›PMID 22967541›Full record

ArticleTalanta2012

New fluorescent pH sensors based on covalently linkable PET rhodamines.

Daniel Aigner, Sergey M Borisov, Francisco J Orriach Fernández, Jorge F Fernández Sánchez, Robert Saf, Ingo Klimant

Abstract read
In one paragraph

Article in Talanta, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. FITC-Labeled Alendronate as an In Vivo Bone pH Sensor.BioMed research international · 2020
    Article
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  5. Article
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Daniel AignerInstitute of Analytical Chemistry and Food Chemistry, Graz University of Technology, Stremayrgasse 9, A-8010 Graz, Austria.
Sergey M Borisov
Francisco J Orriach Fernández
Jorge F Fernández Sánchez
Robert Saf
Ingo Klimant

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A new class of rhodamines for the application as indicator dyes in fluorescent pH sensors is presented. Their pH-sensitivity derives from photoinduced electron transfer between non-protonated amino groups and the excited chromophore which results in effective fluorescence quenching at increasing pH. The new indicator class carries a pentafluorophenyl group at the 9-position of the xanthene core where other rhodamines bear 2-carboxyphenyl substituents instead. The pentafluorophenyl group is used for covalent coupling to sensor matrices by "click" reaction with mercapto groups. Photophysical properties are similar to "classical" rhodamines carrying 2'-carboxy groups. pH sensors have been prepared with two different matrix materials, silica gel and poly(2-hydroxyethylmethacrylate). Both sensors show high luminescence brightness (absolute fluorescence quantum yield Φ(F)≈0.6) and high pH-sensitivity at pH 5-7 which makes them suitable for monitoring biotechnological samples. To underline practical applicability, a dually lifetime referenced sensor containing Cr(III)-doped Al(2)O(3) as reference material is presented.

Indexed as

Photochemical ProcessesElectron TransportFluorescent DyesHalogenationHydrogen-Ion ConcentrationRhodaminesWaterFluorescent DyesRhodaminesWater

Identifiers

PMID22967541
PMCPMC3484401

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.