ArticleFibrogenesis & tissue repair2012
Interventions in Wnt signaling as a novel therapeutic approach to improve myocardial infarct healing.
Article in Fibrogenesis & tissue repair, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Sclerostin aggravates cardiac remodeling after myocardial infarction by inhibition of Wnt/β-catenin signaling pathway.Journal of thoracic disease · 2022Article
- Exendin-4 Attenuates Remodeling in the Remote Myocardium of Rats After an Acute Myocardial Infarction by Activating β-Arrestin-2, Protein Phosphatase 2A, and Glycogen Synthase Kinase-3 and Inhibiting β-Catenin.Cardiovascular drugs and therapy · 2021Article
- Dimethyl fumarate preserves left ventricular infarct integrity following myocardial infarction via modulation of cardiac macrophage and fibroblast oxidative metabolism.Journal of molecular and cellular cardiology · 2021Article
- Molecular regulation of myocardial proliferation and regeneration.Cell regeneration (London, England) · 2021Review
- Role of Adenosine and Purinergic Receptors in Myocardial Infarction: Focus on Different Signal Transduction Pathways.Biomedicines · 2021Review
- Tankyrase Inhibitor for Cardiac Tissue Regeneration: anIranian journal of pharmaceutical research : IJPR · 2021Article
- Ubiquitin-specific protease 2 regulates Ang Ⅱ-induced cardiac fibroblasts activation by up-regulating cyclin D1 and stabilizing β-catenin in vitro.Journal of cellular and molecular medicine · 2021Article
- Discovering small molecules as Wnt inhibitors that promote heart regeneration and injury repair.Journal of molecular cell biology · 2020Article
- MicroRNA-494 Inhibits the LRG1 Expression to Induce Proliferation and Migration of VECs in Rats following Myocardial Infarction.Molecular therapy. Nucleic acids · 2019Article
- The cardiac microenvironment uses non-canonical WNT signaling to activate monocytes after myocardial infarction.EMBO molecular medicine · 2017Article
- Intermittent pacing therapy favorably modulates infarct remodeling.Basic research in cardiology · 2017Article
- Loss of Macrophage Wnt Secretion Improves Remodeling and Function After Myocardial Infarction in Mice.Journal of the American Heart Association · 2017Article
- Cardiac fibrosis in myocardial infarction-from repair and remodeling to regeneration.Cell and tissue research · 2016Review
- UM206, a selective Frizzled antagonist, attenuates adverse remodeling after myocardial infarction in swine.Laboratory investigation; a journal of technical methods and pathology · 2016Article
- Tanshinone IIA pretreatment renders free flaps against hypoxic injury through activating Wnt signaling and upregulating stem cell-related biomarkers.International journal of molecular sciences · 2014Article
- Tanshinone IIA pretreatment protects free flaps against hypoxic injury by upregulating stem cell-related biomarkers in epithelial skin cells.BMC complementary and alternative medicine · 2014Article
- Function and fate of myofibroblasts after myocardial infarction.Fibrogenesis & tissue repair · 2013Article
- Agonists of epoxyeicosatrienoic acids reduce infarct size and ameliorate cardiac dysfunction via activation of HO-1 and Wnt1 canonical pathway.Prostaglandins & other lipid mediatorsArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Following myocardial infarction, wound healing takes place in the infarct area where the non-viable cardiac tissue is replaced by a scar. Inadequate wound healing or insufficient maintenance of the extracellular matrix in the scar can lead to excessive dilatation of the ventricles, one of the hallmarks of congestive heart failure. Therefore, it is important to better understand the wound-healing process in the heart and to develop new therapeutic agents that target the infarct area in order to maintain an adequate cardiac function. One of these potential novel therapeutic targets is Wnt signaling. Wnt signaling plays an important role in embryonic myocardial development but in the adult heart the pathway is thought to be silent. However, there is increasing evidence that components of the Wnt pathway are re-expressed during cardiac repair, implying a regulatory role. Recently, several studies have been published where the effect of interventions in Wnt signaling on infarct healing has been studied. In this review, we will summarize the results of these studies and discuss the effects of these interventions on the different cell types that are involved in the wound healing process.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.