ArticleAmerican journal of physiology. Endocrinology and metabolism2012
PET imaging reveals distinctive roles for different regional adipose tissue depots in systemic glucose metabolism in nonobese humans.
Article in American journal of physiology. Endocrinology and metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 66 citations in OpenAlex.
- Trial
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- Picalm, a novel regulator of GLUT4-trafficking in adipose tissue.Molecular metabolism · 2024Article
- Greater molecular potential for glucose metabolism in adipose tissue and skeletal muscle of women compared with men.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Altered glucose kinetics occurs with aging: a new outlook on metabolic flexibility.American journal of physiology. Endocrinology and metabolism · 2024Article
- A Review of Machine Learning Approaches for Brain Positron Emission Tomography Data Analysis.Nuclear medicine and molecular imaging · 2024Review
- Article
- Hemp seed (The veterinary quarterly · 2023Article
- TNIK is a conserved regulator of glucose and lipid metabolism in obesity.Science advances · 2023Article
- Metabolic Flexibility and Inflexibility: Pathology Underlying Metabolism Dysfunction.Journal of clinical medicine · 2023Article
- The Role of Physical Activity in Nonalcoholic and Metabolic Dysfunction Associated Fatty Liver Disease.Biomedicines · 2021Review
- Total and regional fat-to-muscle mass ratio measured by bioelectrical impedance and risk of incident type 2 diabetes.Journal of cachexia, sarcopenia and muscle · 2021Article
- Skeletal muscle-targeted delivery of Fgf6 protects mice from diet-induced obesity and insulin resistance.JCI insight · 2021Article
- Review
- Adaptive Fat Oxidation Is Coupled with Increased Lipid Storage in Adipose Tissue of Female Mice Fed High Dietary Fat and Sucrose.Nutrients · 2020Article
- Validation of automated whole-body analysis of metabolic and morphological parameters from an integrated FDG-PET/MRI acquisition.Scientific reports · 2020Article
- Effects of High-Intensity Exercise Training on Adipose Tissue Mass, Glucose Uptake and Protein Content in Pre- and Post-menopausal Women.Frontiers in sports and active living · 2020Article
- Muscle and adipose tissue insulin resistance: malady without mechanism?Journal of lipid research · 2019Review
- The RNA binding protein HuR influences skeletal muscle metabolic flexibility in rodents and humans.Metabolism: clinical and experimental · 2019Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Excess amounts of abdominal subcutaneous (SAT) and visceral (VAT) adipose tissue (AT) are associated with insulin resistance, even in normal-weight subjects. In contrast, gluteal-femoral AT (GFAT) is hypothesized to offer protection against insulin resistance. Dynamic PET imaging studies were undertaken to examine the contributions of both metabolic activity and size (volume) of these depots in systemic glucose metabolism. Nonobese, healthy volunteers (n = 15) underwent dynamic PET imaging uptake of [¹⁸F]FDG at a steady-state (20 mU·m⁻²·min⁻¹) insulin infusion. PET images of tissue [¹⁸F]FDG activity were coregistered with MRI to derive K values for insulin-stimulated rates of fractional glucose uptake within tissue. Adipose tissue volume was calculated from DEXA and MRI. VAT had significantly higher rates of fractional glucose uptake per volume than SAT (P < 0.05) or GFAT (P < 0.01). K(GFAT) correlated positively (r = 0.67, P < 0.01) with systemic insulin sensitivity [glucose disappearance rate (R(d))] and negatively with insulin-suppressed FFA (r = -0.71, P < 0.01). SAT (r = -0.70, P < 0.01) and VAT mass (r = -0.55, P < 0.05) correlated negatively with R(d), but GFAT mass did not. We conclude that rates of fractional glucose uptake within GFAT and VAT are significantly and positively associated with systemic insulin sensitivity in nonobese subjects. Furthermore, whereas SAT and VAT amounts are confirmed to relate to systemic insulin resistance, GFAT amount is not associated with insulin resistance. These dynamic PET imaging studies indicate that both quantity and quality of specific AT depots have distinct roles in systemic insulin resistance and may help explain the metabolically obese but normal-weight phenotype.
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