Evidence map›Paper›PMID 22967079›Full record

ReviewExpert review of proteomics2012

Protein biomarkers of alcohol abuse.

Mariana P Torrente, Willard M Freeman, Kent E Vrana

Abstract readReview
In one paragraph

Review in Expert review of proteomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. GeneWeaver: finding consilience in heterogeneous cross-species functional genomics data.Mammalian genome : official journal of the International Mammalian Genome Society · 2015
    Article
  10. Article
  11. Review
  12. Proteomic approaches and identification of novel therapeutic targets for alcoholism.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mariana P TorrenteDepartment of Pharmacology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA.
Willard M Freeman
Kent E Vrana

Funding

Serum Biomarkers of Alcohol Self-Administration in Non-Human PrimatesR01AA016613 · NIAAA · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI VRANA, KENT E · 2007 to 2009
$1.1M
Dynamic Control of Tryptophan Hydroxylase 2:Regulating Brain Serotonin SynthesisF32MH094071 · NIMH · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI TORRENTE, MARIANA PLAZAS · 2011 to 2012
$71k
NIAAA NIH HHS AA016613-03NIAAA NIH HHS R01 AA016613NIMH NIH HHS 5F32MH094071NIMH NIH HHS F32 MH094071
6 · The paper itself

Abstract

Alcohol abuse can lead to a number of health and social issues. Our current inability to accurately assess long-term drinking behaviors is an important obstacle to its diagnosis and treatment. Biomarkers for chronic alcohol consumption have made a number of important advances but have yet to become highly accurate and as accepted as objective tests for other diseases. Thus, there is a crucial need for the development of more sensitive and specific markers of alcohol abuse. Recent advancements in proteomic technologies have greatly increased the potential for alcohol abuse biomarker discovery. Here, the authors review established and novel protein biomarkers for long-term alcohol consumption and the proteomic technologies that have been used in their study.

Indexed as

Affinity LabelsAlcohol DrinkingAlcohol-Induced DisordersAlcoholismBiomarkersClusterinCytokinesGlycerophospholipidsHumansProteomeProteomicsSensitivity and SpecificityTime FactorsTransferrinAffinity LabelsBiomarkersCLU protein, humanClusterinCytokinesGlycerophospholipidsphosphatidylethanolProteomeTransferrin

Identifiers

PMID22967079
PMCPMC3535006

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.