ArticleMalaria journal2012
Status of potential PfATP6 molecular markers for artemisinin resistance in Suriname.
Article in Malaria journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 27 citations in OpenAlex.
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- Perceptions about malaria among Brazilian gold miners in an Amazonian border area: perspectives for malaria elimination strategies.Malaria journal · 2021Article
- Malaria serology data from the Guiana shield: first insight in IgG antibody responses to Plasmodium falciparum, Plasmodium vivax and Plasmodium malariae antigens in Suriname.Malaria journal · 2020Article
- Profiling of the anti-malarial drug candidate SC83288 against artemisinins in Plasmodium falciparum.Malaria journal · 2018Article
- Limited artemisinin resistance-associated polymorphisms in Plasmodium falciparum K13-propeller and PfATPase6 gene isolated from Bioko Island, Equatorial Guinea.International journal for parasitology. Drugs and drug resistance · 2016Article
- Monitoring artemisinin resistance in Plasmodium falciparum: comparison of parasite clearance time by microscopy and real-time PCR and evaluation of mutations in Pfatpase6 gene in Odisha state of India.Parasitology research · 2015Article
- Article
- Malaria on the Guiana Shield: a review of the situation in French Guiana.Memorias do Instituto Oswaldo Cruz · 2014Article
- Molecular characterization of Plasmodium falciparum uracil-DNA glycosylase and its potential as a new anti-malarial drug target.Malaria journal · 2014Article
- Gold mining areas in Suriname: reservoirs of malaria resistance?Infection and drug resistance · 2014Article
- Evidence of an increased incidence of day 3 parasitaemia in Suriname: an indicator of the emerging resistance of Plasmodium falciparum to artemether.Memorias do Instituto Oswaldo Cruz · 2013Article
- Molecular surveillance as monitoring tool for drug-resistant Plasmodium falciparum in Suriname.The American journal of tropical medicine and hygiene · 2013Article
- Made in Europe: will artemisinin resistance emerge in French Guiana?Malaria journal · 2013Article
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3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPolymorphisms within the PfATP6 gene have been indicated as potential molecular markers for artemisinin efficacy. Since 2004, the use of artemisinin combination therapy (ACT) was introduced as first-line treatment of the uncomplicated malaria cases in Suriname. The aim of this research was to determine changes in Suriname in the status of the polymorphic markers in the PfATP6 gene before and after the adoption of the ACT-regimen, particularly of the S769N mutation, which was reported to be associated with in vitro Artemether resistance in the neighboring country French Guiana.
methodsThe PfATP6 gene from Plasmodium falciparum parasites in Suriname was investigated in 28 samples using PCR amplification and restriction enzyme analysis, to assess and determine the prevalence of potentially interesting single nucleotide polymorphisms. The polymorphisms [L263E; A623E; S769N], which may be associated with the artemisinin resistant phenotype were characterized in parasites from three endemic regions before and after the adoption of the ACT-regimen. In addition, the status of these molecular markers was compared in paired P. falciparum isolates from patients with recurring malaria after controlled ACT.
resultsAll the investigated samples exhibit the wild-type genotype at all three positions; L263, A623, S769.
conclusionAll investigated isolates before and after the adoption of the ACT-regimen and independent of endemic region harbored the wild-type genotype for the three investigated polymorphisms. The study revealed that decreased artemisinin susceptibility could occur independent from PfATP6 mutations, challenging the assumption that artemisinin resistance is associated with these mutations in the PfATP6 gene.
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