ArticleWorld journal of gastrointestinal pharmacology and therapeutics2012
Lactose malabsorption and intolerance: What should be the best clinical management?
Article in World journal of gastrointestinal pharmacology and therapeutics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- European guideline on indications, performance, and clinical impact of hydrogen and methane breath tests in adult and pediatric patients: European Association for Gastroenterology, Endoscopy and Nutrition, European Society of Neurogastroenterology and Motility, and European Society for Paediatric Gastroenterology Hepatology and Nutrition consensus.United European gastroenterology journal · 2022Guideline
- Observational
- Clinical outcomes of two lactose-free formulas in the management of acute childhood diarrhea.World journal of clinical pediatrics · 2026Article
- Letter to the editor "The impact of lactose intolerance diagnosis: costs, timing, and quality‑of‑life".Internal and emergency medicine · 2025Article
- The impact of lactose intolerance diagnosis: costs, timing, and quality-of-life.Internal and emergency medicine · 2025Article
- Prebiotic Strategies to Manage Lactose Intolerance Symptoms.Nutrients · 2024Review
- Review
- Lactose intolerance and levothyroxine malabsorption: a review of the literature and report of a series of patients treated with liquid L-T4 without lactose.Frontiers in endocrinology · 2024Review
- Awareness of Lactose Intolerance Disorder in Saudi Arabia Population.Journal of family medicine and primary care · 2022Article
- Review
- Nutrition in Patients with Lactose Malabsorption, Celiac Disease, and Related Disorders.Nutrients · 2021Review
- Development of Personalized Nutrition: Applications in Lactose Intolerance Diagnosis and Management.Nutrients · 2021Review
- Hydrogen Breath Tests: Are They Really Useful in the Nutritional Management of Digestive Disease?Nutrients · 2021Review
- Lactose tolerance test as an alternative to hydrogen breath test in the study of lactose malabsorption.Advances in laboratory medicine · 2020Article
- Article
- Lactose Intolerance: What Your Breath Can Tell You.Diagnostics (Basel, Switzerland) · 2020Review
- Review
- Knowledge and Attitudes Towards Nutrigenetics: Findings from the 2018 Unified Forces Preventive Nutrition Conference (UFPN).Nutrients · 2020Article
- Validity of a Portable Breath Analyser (AIRE) for the Assessment of Lactose Malabsorption.Nutrients · 2019Article
- Association between increased plasma levels of homocysteine and depression observed in individuals with primary lactose malabsorption.PloS one · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lactose malabsorption (LM) is the incomplete hydrolysis of lactose due to lactase deficiency, which may occur as a primary disorder or secondary to other intestinal diseases. Primary adult-type hypolactasia is an autosomal recessive condition resulting from the physiological decline of lactase activity. Different methods have been used to diagnose LM. Lactose breath test represents the most reliable technique. A recent consensus conference has proposed the more physiological dosage of 25 g of lactose and a standardized procedure for breath testing. Recently a new genetic test, based on C/T13910 polymorphism, has been proposed for the diagnosis of adult-type hypolactasia, complementing the role of breath testing. LM represents a well-known cause of abdominal symptoms although only some lactose malabsorbers are also intolerants. Diagnosing lactose intolerance is not straightforward. Many non-malabsorber subjects diagnose themselves as being lactose intolerant. Blind lactose challenge studies should be recommended to obtain objective results. Besides several studies indicate that subjects with lactose intolerance can ingest up to 15 g of lactose with no or minor symptoms. Therefore a therapeutic strategy consists of a lactose restricted diet avoiding the nutritional disadvantages of reduced calcium and vitamin intake.Various pharmacological options are also available. Unfortunately there is insufficient evidence that these therapies are effective. Further double-blind studies are needed to demonstrate treatment effectiveness in lactose intolerance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.