ArticleSchizophrenia research and treatment2012
Faulty suppression of irrelevant material in patients with thought disorder linked to attenuated frontotemporal activation.
Article in Schizophrenia research and treatment, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neural correlates of formal thought disorder: An activation likelihood estimation meta-analysis.Human brain mapping · 2017Pooled it
- Using a self-modulated treadmill as a novel approach to study cognitive-motor and biomechanical outcomes during dual-task walking in individuals with and without lower limb loss.Experimental brain research · 2026Article
- Neurobiological substrates of the positive formal thought disorder in schizophrenia revealed by seed connectome-based predictive modeling.NeuroImage. Clinical · 2021Article
- The influence of semantic associations on sentence production in schizophrenia: an fMRI study.European archives of psychiatry and clinical neuroscience · 2020Article
- Resting state perfusion in the language network is linked to formal thought disorder and poor functional outcome in schizophrenia.Acta psychiatrica Scandinavica · 2017Article
- Abnormal N400 Semantic Priming Effect May Reflect Psychopathological Processes in Schizophrenia: A Twin Study.Schizophrenia research and treatment · 2017Article
- Frequency and neural correlates of pauses in patients with formal thought disorder.Frontiers in psychiatry · 2013Article
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10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Formal thought disorder is a feature schizophrenia that manifests as disorganized, incoherent speech, and is associated with a poor clinical outcome. The neurocognitive basis of this symptom is unclear but it is thought to involve an impairment in semantic processing classically described as a loosening of meaningful associations. Using a paradigm derived from the n400 event-related, potential, we examined the extent to which regional activation during semantic processing is altered in schizophrenic patients with formal thought disorder. Ten healthy control and 18 schizophrenic participants (9 with and 9 without formal thought disorder) performed a semantic decision sentence task during an event-related functional magnetic resonance imaging experiment. We employed analysis of variance to estimate the main effects of semantic congruency and groups on activation and specific effects of formal thought disorder were addressed using post-hoc comparisons. We found that the frontotemporal network, normally engaged by a semantic decision task, was underactivated in schizophrenia, particularly in patients with FTD. This network is implicated in the inhibition of automatically primed stimuli and impairment of its function interferes with language processing and contributes to the production of incoherent speech.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.