ArticlePulmonary medicine2012
Virus infection-induced bronchial asthma exacerbation.
Article in Pulmonary medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 59 citations in OpenAlex.
- Effect of peramivir on respiratory symptom improvement in patients with influenza virus infection and pre-existing chronic respiratory disease: Findings of a randomized, open-label study.Influenza and other respiratory viruses · 2021Trial
- Pyroptosis in asthma: inflammatory phenotypes, immune and non-immune cells, and novel treatment approaches.Frontiers in pharmacology · 2024Review
- Interplay between hypoxia and inflammation contributes to the progression and severity of respiratory viral diseases.Molecular aspects of medicine · 2021Review
- Enhanced airway hyperresponsiveness in asthmatic children and mice with A(H1N1)pdm09 infection.Immunity, inflammation and disease · 2021Article
- Immunological Aspects Related to Viral Infections in Severe Asthma and the Role of Omalizumab.Biomedicines · 2021Review
- The Effect of Unconventional Cytokine Combinations on NK-Cell Responses to Viral Infection.Frontiers in immunology · 2021Review
- Viruses and non-allergen environmental triggers in asthma.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2019Review
- Distal respiratory tract viral infections in young children trigger a marked increase in alveolar mast cells.ERJ open research · 2018Article
- Article
- Mast cells contribute to Enterovirus 71 infection-induced pulmonary edema in neonatal mice.Laboratory investigation; a journal of technical methods and pathology · 2018Article
- Temporal trends and factors associated with pediatric hospitalizations with respiratory infection.The Journal of asthma : official journal of the Association for the Care of Asthma · 2016Article
- Acute effects of viral respiratory tract infections on sputum bacterial density during CF pulmonary exacerbations.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2015Observational
- Screening and functional pathway analysis of genes associated with pediatric allergic asthma using a DNA microarray.Molecular medicine reports · 2015Article
- Infection in severe asthma exacerbations and critical asthma syndrome.Clinical reviews in allergy & immunology · 2015Review
- Mast cells and influenza a virus: association with allergic responses and beyond.Frontiers in immunology · 2015Review
- Respiratory viral infection, epithelial cytokines, and innate lymphoid cells in asthma exacerbations.Journal of leukocyte biology · 2014Review
- Deficiency of melanoma differentiation-associated protein 5 results in exacerbated chronic postviral lung inflammation.American journal of respiratory and critical care medicine · 2014Article
- A GM-CSF/IL-33 pathway facilitates allergic airway responses to sub-threshold house dust mite exposure.PloS one · 2014Article
- Epidemiology of virus-induced asthma exacerbations: with special reference to the role of human rhinovirus.Frontiers in microbiology · 2014Review
- Influenza A(H1N1)pdm09 virus and asthma.Frontiers in microbiology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infection with respiratory viruses, including rhinoviruses, influenza virus, and respiratory syncytial virus, exacerbates asthma, which is associated with processes such as airway inflammation, airway hyperresponsiveness, and mucus hypersecretion. In patients with viral infections and with infection-induced asthma exacerbation, inflammatory mediators and substances, including interleukins (ILs), leukotrienes and histamine, have been identified in the airway secretions, serum, plasma, and urine. Viral infections induce an accumulation of inflammatory cells in the airway mucosa and submucosa, including neutrophils, lymphocytes and eosinophils. Viral infections also enhance the production of inflammatory mediators and substances in airway epithelial cells, mast cells, and other inflammatory cells, such as IL-1, IL-6, IL-8, GM-CSF, RANTES, histamine, and intercellular adhesion molecule-1. Viral infections affect the barrier function of the airway epithelial cells and vascular endothelial cells. Recent reports have demonstrated augmented viral production mediated by an impaired interferon response in the airway epithelial cells of asthma patients. Several drugs used for the treatment of bronchial asthma reduce viral and pro-inflammatory cytokine release from airway epithelial cells infected with viruses. Here, I review the literature on the pathogenesis of the viral infection-induced exacerbation of asthma and on the modulation of viral infection-induced airway inflammation.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.