ReviewOxidative medicine and cellular longevity2012
ROS in aging Caenorhabditis elegans: damage or signaling?
Review in Oxidative medicine and cellular longevity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed.
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- Noncanonical role of MTP-18 in mitochondrial function and aging via electron transport chain interactions in Caenorhabditis elegans.Biogerontology · 2026Article
- The mycosporine-like amino acid "palythine" promotes healthy aging and neuroprotection in Caenorhabditis elegans.Biogerontology · 2026Article
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- RNA-DNA Differences: Mechanisms, Oxidative Stress, Transcriptional Fidelity, and Health Implications.Antioxidants (Basel, Switzerland) · 2025Review
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- Activity-dependent mitochondrial ROS signaling regulates recruitment of glutamate receptors to synapses.eLife · 2024Article
- Bee Venom Toxic Effect on MDA-MB-231 Breast Cancer Cells andAnti-cancer agents in medicinal chemistry · 2024Article
- Neuronal basis and diverse mechanisms of pathogen avoidance inFrontiers in immunology · 2024Review
- Metal copper and silver revealed potent antimicrobial activity for treatingAmerican journal of translational research · 2024Article
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- Sanghuangporus sanghuang extract extended the lifespan and healthspan ofFrontiers in pharmacology · 2023Article
- Anti-Aging Effects of R-Phycocyanin fromMarine drugs · 2022Article
- Protective Effect of Bilberry Anthocyanin Extracts on Dextran Sulfate Sodium-Induced Intestinal Damage inNutrients · 2022Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors.
Funding
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Abstract
Many insights into the mechanisms and signaling pathways underlying aging have resulted from research on the nematode Caenorhabditis elegans. In this paper, we discuss the recent findings that emerged using this model organism concerning the role of reactive oxygen species (ROS) in the aging process. The accrual of oxidative stress and damage has been the predominant mechanistic explanation for the process of aging for many years, but reviewing the recent studies in C. elegans calls this theory into question. Thus, it becomes more and more evident that ROS are not merely toxic byproducts of the oxidative metabolism. Rather it seems more likely that tightly controlled concentrations of ROS and fluctuations in redox potential are important mediators of signaling processes. We therefore discuss some theories that explain how redox signaling may be involved in aging and provide some examples of ROS functions and signaling in C. elegans metabolism. To understand the role of ROS and the redox status in physiology, stress response, development, and aging, there is a rising need for accurate and reversible in vivo detection. Therefore, we comment on some methods of ROS and redox detection with emphasis on the implementation of genetically encoded biosensors in C. elegans.
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