Evidence map›Paper›PMID 22966378›Full record

ArticleOncology letters2010

[Gd@C(82)(OH)(22)](n) nanoparticles inhibit the migration and adhesion of glioblastoma cells.

Jing Wang, Feng Gu, Ting Ding, Xiaoli Liu, Gengmei Xing, Yuliang Zhao, Ning Zhang, Yongjie Ma

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Influence of CCancers · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Jing WangCentral Laboratory of the Oncology Department, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060.
Feng Gu
Ting Ding
Xiaoli Liu
Gengmei Xing
Yuliang Zhao
Ning Zhang
Yongjie Ma
Tianjin Medical University Cancer Institute and Hospital · CNKey Laboratory of Nuclear Radiation and Nuclear Energy Technology · CNInstitute of High Energy Physics · CNTianjin Medical University · CN

Funding

Sex differences in stress-alcohol interactions modulating amygdala activityR00AA021802 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI LOGRIP, MARIAN LEE · 2015 to 2017
$747k
Sex differences in stress-alcohol interactions modulating amygdala activityK99AA021802 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI LOGRIP, MARIAN LEE · 2013 to 2014
$279k
NIAAA NIH HHS K99 AA021802NIAAA NIH HHS R00 AA021802
6 · The paper itself

Abstract

In our previous study, [Gd@C(82)(OH)(22)](n), a fullerene-based nanoparticle, exhibited potent anti-tumor effects in mouse tumor-bearing models without detectable toxicity. The mechanism involved in the anti-tumor effect exerted by [Gd@C(82)(OH)(22)](n) remains to be elucidated. This study found that glioblastoma cells treated with [Gd@C(82)(OH)(22)](n) nanoparticles showed a significant impairment in migration and adhesion by cell chemotaxis, scratch and adhesion assays in vitro. Furthermore, our data showed that the key proteins, CD40 and ICAM-1, were involved in the inhibition of adhesion in the [Gd@C(82)(OH)(22)](n) nanoparticle-treated glioblastoma cells. Thus, our study suggests that the [Gd@C(82)(OH)(22)](n) nanoparticle is a new potential anti-tumor effector and a therapeutic component for malignant glioblastoma infiltration.

Identifiers

PMID22966378
PMCPMC3436416
OpenAlexW2103140753

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.