ArticleOncology letters2010
Methylation of the DLEC1 gene correlates with poor prognosis in Japanese lung cancer patients.
Article in Oncology letters, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The clinicopathological significance and potential drug target of E-cadherin in NSCLC.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Pooled it
- The prognostic value of epigenetic silencing of p16 gene in NSCLC patients: a systematic review and meta-analysis.PloS one · 2013Pooled it
- PMEnvironmental health and preventive medicine · 2020Article
- DLEC1 methylation is associated with a better clinical outcome in patients with intrahepatic cholangiocarcinoma of the small duct subtype.Virchows Archiv : an international journal of pathology · 2019Article
- Article
- Expression level and methylation status of three tumor suppressor genes, DLEC1, ITGA9 and MLH1, in non-small cell lung cancer.Medical oncology (Northwood, London, England) · 2016Article
- The diagnosis value of promoter methylation of UCHL1 in the serum for progression of gastric cancer.BioMed research international · 2015Article
- Development of a multiplex methylation specific PCR suitable for (early) detection of non-small cell lung cancer.Epigenetics · 2014Article
- Methylation of DLEC1 promoter is a predictor for recurrence in Chinese patients with gastric cancer.Disease markers · 2014Article
- Identification of DLEC1 D215N Somatic Mutation in Formalin Fixed Paraffin Embedded Melanoma and Melanocytic Nevi Specimens.Journal of skin cancer · 2013Article
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Authors and funding
6 authors.
Funding
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Abstract
The incidence of chromosome 3p gene alterations is one of the most frequent and earliest documented events in lung cancer. This study aimed to investigate promoter methylation in the deleted in lung and esophageal cancer 1 (DLEC1) gene, as well as the p16 and CDH1 genes in Japanese lung cancer cases. The methylation status of the promoter regions of DLEC1, p16 and CDH1 was investigated using methylation-specific PCR. The findings were compared to the clinicopathological features of lung cancer. Methylation-specific PCR showed that the DLEC1 promoter region was methylated in 65 out of 116 (56%) lung cancers. Patients with DLEC1-methylated cancer were associated with a significantly worse prognosis than those with unmethylated cancer (p=0.0368; hazard ratio=1.83). The p16 methylation status correlated with squamous histology (p=0.03) and smoking status (never smoker vs. smoker; p=0.0122). Patients with p16 ummethylated cancer harbored more EGFR mutations (p=0.0071). The CDH1 promoter region was hypermethylated in 65 out of 118 (55.1%) lung cancer cases. However, the CDH1 methylation status was not associated with the clinicopathological characteristics of the lung cancer types. p16 and CDH1 methylation status did not correlate with survival in the lung cancer patients. Thus, in our Japanese cohort, the methylation status of the DLEC1 gene was a marker of poor prognosis independent of stage.
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