ArticleInternational journal of cell biology2012
Molecular Regulation of the Mitochondrial F(1)F(o)-ATPsynthase: Physiological and Pathological Significance of the Inhibitory Factor 1 (IF(1)).
Article in International journal of cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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Who cites it
40 citing papers in PubMed.
- Troponin: biology, molecular mechanisms, and multidimensional clinical applications.Molecular biomedicine · 2026Review
- Mitochondrial Permeability Transition Regulators As Emerging Therapeutic Targets in Aging and Neurodegeneration: Recent Insights.Journal of molecular neuroscience : MN · 2026Review
- Mitochondrial metabolic imbalance drives diploidization in mouse haploid embryonic stem cells via NADPH overload.Nature communications · 2026Article
- Role of circRNAs in regulating cell death in cancer: a comprehensive review.Cell biochemistry and biophysics · 2025Review
- Differential Expression of Nuclear-Encoded Mitochondrial Protein Genes of ATP Synthase Across Different Tissues of Female Buffalo.Molecular biotechnology · 2025Article
- Regulatory effects of trimetazidine in cardiac ischemia/reperfusion injury.Naunyn-Schmiedeberg's archives of pharmacology · 2023Review
- Inhibiting Succinate Release Worsens Cardiac Reperfusion Injury by Enhancing Mitochondrial Reactive Oxygen Species Generation.Journal of the American Heart Association · 2022Article
- Identification of New Proteins and Potential Mitochondrial FPlants (Basel, Switzerland) · 2021Article
- Circular RNAs act as regulators of autophagy in cancer.Molecular therapy oncolytics · 2021Review
- Links between mitochondrial retrograde response and mitophagy in pathogenic cell signalling.Cellular and molecular life sciences : CMLS · 2021Review
- Molecular and Supramolecular Structure of the Mitochondrial Oxidative Phosphorylation System: Implications for Pathology.Life (Basel, Switzerland) · 2021Review
- NH-sulfoximine: A novel pharmacological inhibitor of the mitochondrial FBritish journal of pharmacology · 2021Article
- Inhibition of the mitochondrial ATPase function by IF1 changes the spatiotemporal organization of ATP synthase.Biochimica et biophysica acta. Bioenergetics · 2021Article
- Current understanding of structure, function and biogenesis of yeast mitochondrial ATP synthase.Journal of bioenergetics and biomembranes · 2019Review
- Protective mechanism of shenmai on myocardial ischemia-reperfusion through the energy metabolism pathway.American journal of translational research · 2019Article
- Berberine chloride mediates its antileishmanial activity by inhibiting Leishmania mitochondria.Parasitology research · 2019Article
- Control of rotation of the FJournal of bioenergetics and biomembranes · 2018Review
- Reduction of the ATPase inhibitory factor 1 (IFCell death & disease · 2018Article
- The miR-29 transcriptome in endocrine-sensitive and resistant breast cancer cells.Scientific reports · 2017Article
- Ginsenoside Rb1 protects against ischemia/reperfusion-induced myocardial injury via energy metabolism regulation mediated by RhoA signaling pathway.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In mammals, the mitochondrial F(1)F(o)-ATPsynthase sets out the energy homeostasis by producing the bulk of cellular ATP. As for every enzyme, the laws of thermodynamics command it; however, it is privileged to have a dedicated molecular regulator that controls its rotation. This is the so-called ATPase Inhibitory Factor 1 (IF(1)) that blocks its reversal to avoid the consumption of cellular ATP when the enzyme acts as an ATP hydrolase. Recent evidence has also demonstrated that IF(1) may control the alignment of the enzyme along the mitochondrial inner membrane, thus increasing the interest for the molecule. We conceived this review to outline the fundamental knowledge of the F(1)F(o)-ATPsynthase and link it to the molecular mechanisms by which IF(1) regulates its way of function, with the ultimate goal to highlight this as an important and possibly unique means to control this indispensable enzyme in both physiological and pathological settings.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.