ArticleDiabetes2013
Tub has a key role in insulin and leptin signaling and action in vivo in hypothalamic nuclei.
Article in Diabetes, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- TUB gene expression in hypothalamus and adipose tissue and its association with obesity in humans.International journal of obesity (2005) · 2018Pooled it
- A novel homozygous TUB mutation associated with autosomal recessive retinitis pigmentosa in a consanguineous Chinese family.BMC medical genomics · 2023Article
- Tubby-like proteins (TLPs) transcription factor in different regulatory mechanism in plants: a review.Plant molecular biology · 2022Review
- Biallelic InactivatingInternational journal of molecular sciences · 2022Article
- Gene expression atlas of energy balance brain regions.JCI insight · 2021Article
- Neuroprotective Effects of Protein Tyrosine Phosphatase 1B Inhibition against ER Stress-Induced Toxicity.Molecules and cells · 2017Article
- Cdc2-like kinase 2 in the hypothalamus is necessary to maintain energy homeostasis.International journal of obesity (2005) · 2017Article
- C-terminally mutated tubby protein accumulates in aggresomes.BMB reports · 2017Article
- Hypothalamic Phosphodiesterase 3B Pathway Mediates Anorectic and Body Weight-Reducing Effects of Insulin in Male Mice.Neuroendocrinology · 2017Article
- A novel role for protein tyrosine phosphatase 1B as a positive regulator of neuroinflammation.Journal of neuroinflammation · 2016Article
- Recent Progress in the Understanding of Obesity: Contributions of Genome-Wide Association Studies.Current obesity reports · 2015Review
- Review
- A homozygous mutation in the TUB gene associated with retinal dystrophy and obesity.Human mutation · 2014Article
- The STK33-linked SNP rs4929949 is associated with obesity and BMI in two independent cohorts of Swedish and Greek children.PloS one · 2013Article
- Central regulation of metabolism by protein tyrosine phosphatases.Frontiers in neuroscience · 2012Article
- Retracted: Treadmill Training Increases SIRT-1 and PGC-1Mediators of inflammationArticle
Corrections and comments
- Retraction · 2017-02-10Concerns/Issues about Data · Duplication of/in Image · Investigation by Journal/Publisher · Manipulation of Images · Upgrade/Update of Prior Notice(s) · · This article was subsequently retracted (2017); For more information, see RW posts about MJA Saad: http://retractionwatch.com/category/by-author/mario-saad/;
- Expression of concern · 2016-03-24Concerns/Issues about Data · Duplication of/in Image · Investigation by Company/Institution · Investigation by Journal/Publisher · Manipulation of Images · · Investigation by institution was requested by journal/association; This article was subsequently retracted (2017); For more information, see RW posts about MJA Saad: http://retractionwatch.com/category/by-author/mario-saad/;
- Expression of concern
- Retracted
Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutation of tub gene in mice induces obesity, suggesting that tub could be an important regulator of energy balance. In the current study, we investigated whether insulin, leptin, and obesity can modulate Tub in vivo in hypothalamic nuclei, and we investigated possible consequences on energy balance, neuropeptide expression, and hepatic glucose metabolism. Food intake, metabolic characteristics, signaling proteins, and neuropeptide expression were measured in response to fasting and refeeding, intracerebroventricular insulin and leptin, and Tub antisense oligonucleotide (ASO). Tub tyrosine phosphorylation (Tub-p-tyr) is modulated by nutritional status. Tub is a substrate of insulin receptor tyrosine kinase (IRTK) and leptin receptor (LEPR)-Janus kinase 2 (JAK2) in hypothalamic nuclei. After leptin or insulin stimulation, Tub translocates to the nucleus. Inhibition of Tub expression in hypothalamus by ASO increased food intake, fasting blood glucose, and hepatic glucose output, decreased O(2) consumption, and blunted the effect of insulin or leptin on proopiomelanocortin, thyroid-releasing hormone, melanin-concentrating hormone, and orexin expression. In hypothalamus of mice administered a high-fat diet, there is a reduction in leptin and insulin-induced Tub-p-tyr and nuclear translocation, which is reversed by reducing protein tyrosine phosphatase 1B expression. These results indicate that Tub has a key role in the control of insulin and leptin effects on food intake, and the modulation of Tub may contribute to insulin and leptin resistance in DIO mice.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.