ArticleInfection and immunity2012
Escherichia coli isolates that carry vat, fyuA, chuA, and yfcV efficiently colonize the urinary tract.
Article in Infection and immunity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 175 papers.
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Who cites it
175 citing papers in PubMed.
- Article
- A rapid, inexpensive diagnostic for bacterial pathogen and resistance detection in resource-limited settings.Science advances · 2026Article
- Phylogenetic analysis and characterization of hybrid enteroaggregative/uropathogenic Escherichia coli strains isolated from urinary tract infection.Molecular biology reports · 2026Article
- Virulence and Invasion Profiles ofPathogens (Basel, Switzerland) · 2026Article
- Genomic Characterization of Selected Multidrug-ResistantAnimals : an open access journal from MDPI · 2026Article
- Cyclomodulins and supplementary virulence genes as determinants of clinical severity and antimicrobial resistance in uropathogenic Escherichia coli and Klebsiella pneumoniae.World journal of microbiology & biotechnology · 2026Article
- Engineered gut symbionts mediate cross-phylum antagonism to suppress uropathogenicbioRxiv : the preprint server for biology · 2026Article
- Characterization of Antimicrobial Resistance and Potential Zoonotic Risk in UropathogenicTropical medicine and infectious disease · 2026Article
- Prevalence, antibiotic resistance, and virulence gene profiles of uropathogenic Escherichia coli (UPEC) isolated from raw milk: implications for public health.Folia microbiologica · 2026Article
- Fluoroquinolone-Resistant Avian PathogenicPathogens (Basel, Switzerland) · 2026Article
- Clinical and molecular characterization of NDM-9 and NDM-13 producing multidrug-resistant Escherichia coli strains in China.BMC microbiology · 2026Article
- Genomic and virulence characterization of OXA-48-producingFrontiers in microbiology · 2026Article
- Whole-genome characterisation of high-risk ST131 and the emerging ST1193 UPEC lineages in Romanian patients with recurrent urinary tract infections.Frontiers in microbiology · 2026Article
- The Bacterial Swiss Army Knife: ExPEC Utilizes Multiple Resistance Mechanisms to Counteract Host Immune Responses.Vaccines · 2025Review
- Infective endocarditis caused byThe Journal of international medical research · 2025Article
- Emergence of porcine-derived hybridVirulence · 2025Article
- Molecular Characterization and Antibiotic Resistance of Avian PathogenicAnimals : an open access journal from MDPI · 2025Article
- Prevalence, antimicrobial susceptibility, and virulence profiles of fluoroquinolone-resistant Escherichia coli isolated from companion animals in Sapporo, Japan.The Journal of veterinary medical science · 2025Article
- Shiga Toxin-ProducingMicroorganisms · 2025Article
- Comparative Analysis of ESBL Phenotypes and Antimicrobial Resistance inMicrobial drug resistance (Larchmont, N.Y.) · 2025Article
115 more citing papers are in PubMed but not listed here.
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Abstract
Extraintestinal Escherichia coli (ExPEC), a heterogeneous group of pathogens, encompasses avian, neonatal meningitis, and uropathogenic E. coli strains. While several virulence factors are associated with ExPEC, there is no core set of virulence factors that can be used to definitively differentiate these pathotypes. Here we describe a multiplex of four virulence factor-encoding genes, yfcV, vat, fyuA, and chuA, highly associated with uropathogenic E. coli strains that can distinguish three groups of E. coli: diarrheagenic and animal-associated E. coli strains, human commensal and avian pathogenic E. coli strains, and uropathogenic and neonatal meningitis E. coli strains. Furthermore, human intestinal isolates that encode all four predictor genes express them during exponential growth in human urine and colonize the bladder in the mouse model of ascending urinary tract infection in higher numbers than human commensal strains that do not encode the four predictor genes (P = 0.02), suggesting that the presence of the predictors correlates with uropathogenic potential.
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