Trial reportHypertension (Dallas, Tex. : 1979)2012
Neuropeptide Y promoter polymorphism modifies effects of a weight-loss diet on 2-year changes of blood pressure: the preventing overweight using novel dietary strategies trial.
Trial report in Hypertension (Dallas, Tex. : 1979), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Impact of fatty diets on blood pressure: A systematic review and meta-analysis.Asia Pacific journal of clinical nutrition · 2025Pooled it
- Associations between Genotype-Diet Interactions and Weight Loss-A Systematic Review.Nutrients · 2020Pooled it
- Markers of dietary protein intake are associated with successful weight loss in the POUNDS Lost trial.Clinical obesity · 2017Trial
- Neuropeptide Y genotype, central obesity, and abdominal fat distribution: the POUNDS LOST trial.The American journal of clinical nutrition · 2015Trial
- PCSK7 genotype modifies effect of a weight-loss diet on 2-year changes of insulin resistance: the POUNDS LOST trial.Diabetes care · 2015Trial
- IRS1 genotype modulates metabolic syndrome reversion in response to 2-year weight-loss diet intervention: the POUNDS LOST trial.Diabetes care · 2013Trial
- Link between emotional and external eating behaviors, peripheral neuropeptide Y, and β-hydroxybutyrate in participants with obesity on 12-week ketogenic diet.Nutrition and health · 2026Article
- Genome-Wide Approach of Gene-Nutrient Intake Interaction Study for Essential Hypertension in a Large Korean Cohort (KoGES).Nutrients · 2024Article
- Genome-Wide Interaction Analysis With DASH Diet Score Identified Novel Loci for Systolic Blood Pressure.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Precision Nutrition Unveiled: Gene-Nutrient Interactions, Microbiota Dynamics, and Lifestyle Factors in Obesity Management.Nutrients · 2024Review
- Nutrigenetic variants and response to diet/lifestyle intervention in obese subjects: a pilot study.Acta diabetologica · 2022Article
- Genomic Determinants of Hypertension With a Focus on Metabolomics and the Gut Microbiome.American journal of hypertension · 2020Review
- Berberine for Appetite Suppressant and Prevention of Obesity.BioMed research international · 2020Article
- Higher Serum Neuropeptide Y Levels Are Associated with Metabolically Unhealthy Obesity in Obese Chinese Adults: A Cross-Sectional Study.Mediators of inflammation · 2020Article
- Lessons Learned from the POUNDS Lost Study: Genetic, Metabolic, and Behavioral Factors Affecting Changes in Body Weight, Body Composition, and Cardiometabolic Risk.Current obesity reports · 2019Review
- Gene and environmental interactions according to the components of lifestyle modifications in hypertension guidelines.Environmental health and preventive medicine · 2019Review
- Interplay between diet and genetic susceptibility in obesity and related traits.Frontiers of medicine · 2018Review
- Gene-Diet Interaction and Precision Nutrition in Obesity.International journal of molecular sciences · 2017Review
- Effect of dipeptidyl peptidase 4 inhibition on arterial blood pressure is context dependent.Hypertension (Dallas, Tex. : 1979) · 2015Article
- Obesity-associated hypertension: recent progress in deciphering the pathogenesis.Hypertension (Dallas, Tex. : 1979) · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Neuropeptide Y (NPY) is implicated in the regulation of blood pressure (BP), and NPY pathways in the hypothalamus are sensitive to dietary fat. We evaluated the potential effect of a functional variant rs16147 located in the NPY gene promoter region on the association between 2-year diet intervention and change in multiple BP measures in the randomized Preventing Overweight Using Novel Dietary Strategies Trial. The NPY rs16147 was genotyped in 723 obese adults who were randomly assigned to 1 of 4 diets differing in the target percentages of energy derived from fat, protein, and carbohydrate. The changes of 4 BP phenotypes, including systolic BP, diastolic BP, pulse pressure, and mean arterial pressure, during 2-year diet intervention were analyzed. In the total participants and participants with hypertension, we observed significant and consistent interactions between rs16147 genotype and dietary fat intake on changes in multiple BP phenotypes at 2 years (all P for interactions <0.05). The risk allele (C allele) was associated with a greater reduction of BP phenotypes in response to low-fat diet, whereas an opposite genetic effect was observed in response to high-fat diet. In addition, the C allele was related to greater changes in 4 BP phenotypes in hypertensive compared with nonhypertensive participants. Our data suggest that NPY rs16147 may modulate the association between dietary fat intake and changes in BP phenotypes, and the C allele exerts a long-term beneficial effect on lowering BP in response to low-fat diet in obese and hypertensive subjects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.