ArticleProceedings of the National Academy of Sciences of the United States of America1990
Specific high molecular weight mRNAs induced by associative learning in Hermissenda.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Binding of Gd(3+) to the neuronal signalling protein calexcitin identifies an exchangeable Ca(2+)-binding site.Acta crystallographica. Section F, Structural biology communications · 2016Article
- Critical period of memory enhancement during taste avoidance conditioning in Lymnaea stagnalis.PloS one · 2013Article
- Protein synthesis required for long-term memory is induced by PKC activation on days before associative learning.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Alzheimer and beta-amyloid-treated fibroblasts demonstrate a decrease in a memory-associated GTP-binding protein, Cp20.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- GTP-binding proteins and potassium channels involved in synaptic plasticity and learning.Molecular neurobiology · 1991Review
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Authors and funding
2 authors.
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Abstract
Associative conditioning of Hermissenda crassicornis has been demonstrated to result in long-term changes in the potassium currents IA and ICa2(+)-K+ in photoreceptor neurons in the eye and to increase mRNA levels in the eye 2- to 3-fold. mRNA isolated from Hermissenda trained with paired light and rotation stimuli was labeled with [3H]acetic anhydride, while mRNA from naive animals or from animals subjected to random light and rotation stimuli was labeled with [14C]acetic anhydride. The labeled RNA was combined and separated by agarose gel electrophoresis. The overall size distribution of labeled mRNA was shifted to longer chain lengths in the paired group. In addition, the 3H/14C ratios were markedly increased for 21 distinct size bands, indicating increased mRNA of specific chain lengths in the paired group. Increases in the same size bands were also observed with mRNA labeled in vivo with 32Pi. This indicates that associative learning in Hermissenda results in a specific induction of a distinct set of at least 21 mRNAs, rather than in a generalized increase in synthesis of all mRNA, thus resembling in some respects a differentiation-like response.
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