Evidence map›Paper›PMID 22965356›Full record

ReviewNature reviews. Genetics2012

The telomere syndromes.

Mary Armanios, Elizabeth H Blackburn

Erratum issuedAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 552 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
552citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

552 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  17. Interstitial lung disease and the STING pathway.The Journal of clinical investigation · 2026
    Review
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  20. Article

492 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

2 authors.

Mary ArmaniosDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA. marmani1@jhmi.edu
Elizabeth H Blackburn

Funding

The Role of Telomere Shortening in MDS-AML Pathogenesis (resubmission)R01CA160433 · NCI · JOHNS HOPKINS UNIVERSITY · PI ARMANIOS, MARY Y · 2012 to 2016
$1.7M
The Role of Short Telomeres in Emphysema PathogenesisR21HL104345 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI ARMANIOS, MARY Y · 2011 to 2012
$451k
NCI NIH HHS R01 CA160433NHLBI NIH HHS R21 HL104345
6 · The paper itself

Abstract

There has been mounting evidence of a causal role for telomere dysfunction in a number of degenerative disorders. Their manifestations encompass common disease states such as idiopathic pulmonary fibrosis and bone marrow failure. Although these disorders seem to be clinically diverse, collectively they comprise a single syndrome spectrum defined by the short telomere defect. Here we review the manifestations and unique genetics of telomere syndromes. We also discuss their underlying molecular mechanisms and significance for understanding common age-related disease processes.

Indexed as

AnimalsGenetic Association StudiesGenetic Diseases, InbornGenetic Predisposition to DiseaseHumansModels, BiologicalQuantitative Trait, HeritableSyndromeTelomere

Identifiers

PMID22965356
PMCPMC3548426

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.