ArticleJournal of neuropathology and experimental neurology2012
Motoneuron replacement for reinnervation of skeletal muscle in adult rats.
Article in Journal of neuropathology and experimental neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- The fate of the neuromuscular junction in peripheral nerve injury - current understanding and future research aims: A scoping review.JPRAS open · 2026Review
- Functional Reconstruction of Denervated Muscle by Xenotransplantation of Neural Cells from Porcine to Rat.International journal of molecular sciences · 2022Article
- Preliminary Study of S100B and Sema3A Expression Patterns in Regenerating Muscle Implicates P75-Expressing Terminal Schwann Cells and Muscle Satellite Cells in Neuromuscular Junction Restoration.Frontiers in cell and developmental biology · 2022Article
- Innervation: the missing link for biofabricated tissues and organs.NPJ Regenerative medicine · 2020Review
- Transplanting Cells for Spinal Cord Repair: Who, What, When, Where and Why?Cell transplantation · 2019Article
- Morphological Regeneration and Functional Recovery of Neuromuscular Junctions after Tourniquet-Induced Injuries in Mouse Hindlimb.Frontiers in physiology · 2017Article
- Successful transplantation of motoneurons into the peripheral nerve depends on the number of transplanted cells.Nagoya journal of medical science · 2015Article
- Hypergravity stimulation enhances PC12 neuron-like cell differentiation.BioMed research international · 2015Article
- Electrical stimulation of transplanted motoneurons improves motor unit formation.Journal of neurophysiology · 2014Article
- Electrical stimulation of embryonic neurons for 1 hour improves axon regeneration and the number of reinnervated muscles that function.Journal of neuropathology and experimental neurology · 2013Article
- Acute stimulation of transplanted neurons improves motoneuron survival, axon growth, and muscle reinnervation.Journal of neurotrauma · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Reinnervation is needed to rescue muscle when motoneurons die in disease or injury. Embryonic ventral spinal cord cells transplanted into peripheral nerve reinnervate muscle and reduce atrophy, but low motoneuron survival may limit motor unit formation. We tested whether transplantation of a purified population of embryonic motoneurons into peripheral nerve (mean ± SE, 146,458 ± 4,011 motoneurons) resulted in more motor units and reinnervation than transplantation of a mixed population of ventral spinal cord cells (72,075 ± 12,329 motoneurons). Ten weeks after either kind of transplant, similar numbers of neurons expressed choline acetyl transferase and/or Islet-1. Motoneuron numbers always exceeded the reinnervated motor unit count. Most motor end plate were simple plaques. Reinnervation significantly reduced muscle fiber atrophy. These data show that the number of transplanted motoneurons and motoneuron survival do not limit muscle reinnervation. Incomplete differentiation of motoneurons in nerve and lack of muscle activity may result in immature neuromuscular junctions that limit reinnervation and function.
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