ReviewBone marrow transplantation2013
Rescuing the neonatal brain from hypoxic injury with autologous cord blood.
Review in Bone marrow transplantation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02551003 (A Multi-Centre Safety and Efficacy Study of Autologous Cord Blood Combined With Therapeutic Hypothermia Following Neonates Encephalopathy in China), which is not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multi-Centre Safety and Efficacy Study of Autologous Cord Blood Combined With Therapeutic Hypothermia Following Neonates Encephalopathy in China
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Umbilical cord milking versus delayed cord clamping in term infants: a systematic review and meta-analysis.Journal of perinatology : official journal of the California Perinatal Association · 2021Pooled it
- The Effects of Delayed Cord Clamping on 12-Month Brain Myelin Content and Neurodevelopment: A Randomized Controlled Trial.American journal of perinatology · 2022Trial
- Umbilical cord milking for neonates who are depressed at birth: a randomized trial of feasibility.Journal of perinatology : official journal of the California Perinatal Association · 2018Trial
- Article
- Early transcriptional responses reveal cell type-specific vulnerability and neuroprotective mechanisms in the neonatal ischemic hippocampus.Acta neuropathologica communications · 2025Article
- Article
- Early Postnatal Expression of Tgfβ-1 and Fgf-2 Correlates With Regenerative Functions of Unrestricted Somatic Stem Cell Infusion After Rabbit GMH-IVH.Stem cells translational medicine · 2023Article
- Umbilical cord milking-benefits and risks.Frontiers in pediatrics · 2023Review
- Editorial: Umbilical cord milking-benefits and potential harmful effects.Frontiers in pediatrics · 2023Article
- Placental transfusion: may the "force" be with the baby.Journal of perinatology : official journal of the California Perinatal Association · 2021Review
- Diverse actions of cord blood cell therapy for hypoxic-ischemic encephalopathy.Pediatrics international : official journal of the Japan Pediatric Society · 2021Review
- Autologous cord blood cell therapy for neonatal hypoxic-ischaemic encephalopathy: a pilot study for feasibility and safety.Scientific reports · 2020Article
- Commentary - Exosomes: Realization of the great therapeutic potential of stem cells.Journal of neonatal-perinatal medicine · 2020Article
- Progesterone as a Postnatal Prophylactic Agent for Encephalopathy Caused by Prenatal Hypoxic Ischemic Insult.Endocrinology · 2018Article
- Treating childhood traumatic brain injury with autologous stem cell therapy.Expert opinion on biological therapy · 2018Review
- Priming of the Cells: Hypoxic Preconditioning for Stem Cell Therapy.Chinese medical journal · 2017Review
- Rat umbilical cord blood cells attenuate hypoxic-ischemic brain injury in neonatal rats.Scientific reports · 2017Article
- Umbilical Cord Blood NOS1 as a Potential Biomarker of Neonatal Encephalopathy.Frontiers in pediatrics · 2017Article
- Neonatal Hypoxia Ischaemia: Mechanisms, Models, and Therapeutic Challenges.Frontiers in cellular neuroscience · 2017Review
- Perinatal Brain Injury As a Consequence of Preterm Birth and Intrauterine Inflammation: Designing Targeted Stem Cell Therapies.Frontiers in neuroscience · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain injury resulting from perinatal hypoxic-ischemic encephalopathy (HIE) is a major cause of acute mortality in infants and chronic neurologic disability in surviving children. Recent multicenter clinical trials demonstrated the effectiveness of hypothermia initiated within the first 6 postnatal hours to reduce the risk of death or major neurological disabilities among neonates with HIE. However, in these trials, approximately 40% of cooled infants died or survived with significant impairments. Therefore, adjunct therapies are required to improve the outcome in neonates with HIE. Cord blood (CB) is a rich source of stem cells. Administration of human CB cells in animal models of HIE has generally resulted in improved outcomes and multiple mechanisms have been suggested including anti-inflammation, release of neurotrophic factors and stimulation of endogenous neurogenesis. Investigators at Duke are conducting studies of autologous CB infusion in neonates with HIE and in children with cerebral palsy. These pilot studies indicate no added risk from the regimens used, but results of ongoing placebo-controlled trials are needed to assess efficacy. Meanwhile, further investigations are warranted to determine the best strategies, that is, timing, dosing, route of delivery, choice of stem cells and ex vivo modulations, to attain long-term benefits of CB stem cell therapy.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.