ArticleNanotoxicology2013
Combination of small size and carboxyl functionalisation causes cytotoxicity of short carbon nanotubes.
Article in Nanotoxicology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 27 citations in OpenAlex.
- Prometastatic Potential of Non-Functionalized Multiwalled Carbon Nanotubes in the MDA-MB-436 Breast Cancer Cell Line Model.International journal of molecular sciences · 2025Article
- Physicochemical characterization and genotoxicity of the broad class of carbon nanotubes and nanofibers used or produced in U.S. facilities.Particle and fibre toxicology · 2020Article
- Quantitative Flow Cytometric Evaluation of Oxidative Stress and Mitochondrial Impairment in RAW 264.7 Macrophages after Exposure to Pristine, Acid Functionalized, or Annealed Carbon Nanotubes.Nanomaterials (Basel, Switzerland) · 2020Article
- Comparison of cytotoxicity and membrane efflux pump inhibition in HepG2 cells induced by single-walled carbon nanotubes with different length and functional groups.Scientific reports · 2019Article
- Role of omics techniques in the toxicity testing of nanoparticles.Journal of nanobiotechnology · 2017Review
- Evaluating the mechanistic evidence and key data gaps in assessing the potential carcinogenicity of carbon nanotubes and nanofibers in humans.Critical reviews in toxicology · 2017Review
- Induction of cancer-associated fibroblast-like cells by carbon nanotubes dictates its tumorigenicity.Scientific reports · 2016Article
- Carboxylated short single-walled carbon nanotubes but not plain and multi-walled short carbon nanotubes show in vitro genotoxicity.Toxicological sciences : an official journal of the Society of Toxicology · 2015Article
- Use of whole genome expression analysis in the toxicity screening of nanoparticles.Toxicology and applied pharmacology · 2014Article
- Cellular targets and mechanisms in the cytotoxic action of non-biodegradable engineered nanoparticles.Current drug metabolism · 2013Review
- Suitability of cell-based label-free detection for cytotoxicity screening of carbon nanotubes.BioMed research international · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The use of carbon nanotubes (CNTs) could improve medical diagnosis and treatment provided they show no adverse effects in the organism. In this study, short CNTs with different diameters with and without carboxyl surface functionalisation were assessed. After physicochemical characterisation, cytotoxicity in phagocytic and non-phagocytic cells was determined. The role of oxidative stress was evaluated according to the intracellular glutathione levels and protection by N-acetyl cysteine (NAC). In addition to this, the mode of cell death was also investigated. CNTs <8 nm acted more cytotoxic than CNTs ≥20 nm and carboxylated CNTs more than pristine CNTs. Protection by NAC was maximal for large diameter pristine CNTs and minimal for small diameter carboxylated CNTs. Thin (<8 nm) CNTs acted mainly by disruption of membrane integrity and CNTs with larger diameter induced mainly apoptotic changes. It is concluded that cytotoxicity of small carboxylated CNTs occurs by necrosis and cannot be prevented by antioxidants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.