ArticleMicrocirculation (New York, N.Y. : 1994)2013
Air pollution particulate matter collected from an Appalachian mountaintop mining site induces microvascular dysfunction.
Article in Microcirculation (New York, N.Y. : 1994), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review of community health impacts of mountaintop removal mining.Environment international · 2017Pooled it
- Inhalation exposure to surrogate military burn pit emissions impairs systemic microvascular function: linking pulmonary insult and diverse peripheral responses.Particle and fibre toxicology · 2026Article
- Therapeutic nanoparticle safety in pregnancy: Bridging knowledge gaps with environmental insights and a translational roadmap.Journal of controlled release : official journal of the Controlled Release Society · 2025Review
- Single pulmonary nanopolystyrene exposure in late-stage pregnancy dysregulates maternal and fetal cardiovascular function.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
- Identifying exposure pathways mediating adverse birth outcomes near active surface mines in Central Appalachia.Environmental epidemiology (Philadelphia, Pa.) · 2022Article
- Particulate matter air pollutants and cardiovascular disease: Strategies for intervention.Pharmacology & therapeutics · 2021Review
- Adrenergic and Glucocorticoid Receptors in the Pulmonary Health Effects of Air Pollution.Toxics · 2021Review
- Endothelial progenitor cells as critical mediators of environmental air pollution-induced cardiovascular toxicity.American journal of physiology. Heart and circulatory physiology · 2021Review
- Air Pollution Emissions 2008-2018 from Australian Coal Mining: Implications for Public and Occupational Health.International journal of environmental research and public health · 2020Article
- Microvascular Dysfunction Following Multiwalled Carbon Nanotube Exposure Is Mediated by Thrombospondin-1 Receptor CD47.Toxicological sciences : an official journal of the Society of Toxicology · 2018Article
- Mapping the yearly extent of surface coal mining in Central Appalachia using Landsat and Google Earth Engine.PloS one · 2018Article
- Insulin sensitizers prevent fine particulate matter-induced vascular insulin resistance and changes in endothelial progenitor cell homeostasis.American journal of physiology. Heart and circulatory physiology · 2016Article
- The Impact of Multipollutant Clusters on the Association Between Fine Particulate Air Pollution and Microvascular Function.Epidemiology (Cambridge, Mass.) · 2016Article
- Cardiac and mitochondrial dysfunction following acute pulmonary exposure to mountaintop removal mining particulate matter.American journal of physiology. Heart and circulatory physiology · 2015Article
- Atmospheric particulate matter in proximity to mountaintop coal mines: sources and potential environmental and human health impacts.Environmental geochemistry and health · 2015Article
- Environmentally persistent free radicals compromise left ventricular function during ischemia/reperfusion injury.American journal of physiology. Heart and circulatory physiology · 2015Article
- Appalachian mountaintop mining particulate matter induces neoplastic transformation of human bronchial epithelial cells and promotes tumor formation.Environmental science & technology · 2014Article
- Atmospheric particulate matter size distribution and concentration in West Virginia coal mining and non-mining areas.Journal of exposure science & environmental epidemiology · 2014Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveAir pollution PM is associated with cardiovascular morbidity and mortality. In Appalachia, PM from mining may represent a health burden to this sensitive population that leads the nation in cardiovascular disease, among others. Cardiovascular consequences following inhalation of PM(MTM) are unclear, but must be identified to establish causal effects.
methodsPM was collected within 1 mile of an active MTM site in southern WV. The PM was extracted and was primarily <10 μm in diameter (PM10), consisting largely of sulfur (38%) and silica (24%). Adult male rats were IT with 300 μg PM(MTM) . Twenty-four hours following exposure, rats were prepared for intravital microscopy, or isolated arteriole experiments.
resultsPM(MTM) exposure blunted endothelium-dependent dilation in mesenteric and coronary arterioles by 26%, and 25%, respectively, as well as endothelium-independent dilation. In vivo, PM(MTM) exposure inhibited endothelium-dependent arteriolar dilation (60% reduction). α-adrenergic receptor blockade inhibited PVNS-induced vasoconstriction in exposed animals compared with sham.
conclusionsThese data suggest that PM(MTM) exposure impairs microvascular function in disparate microvascular beds, through alterations in NO-mediated dilation and sympathetic nerve influences. Microvascular dysfunction may contribute to cardiovascular disease in regions with MTM sites.
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