ArticleNutrition & metabolism2012
Early nocturnal meal skipping alters the peripheral clock and increases lipogenesis in mice.
Article in Nutrition & metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 65 citations in OpenAlex.
- Skipping Breakfast for 6 Days Delayed the Circadian Rhythm of the Body Temperature without Altering Clock Gene Expression in Human Leukocytes.Nutrients · 2020Trial
- Review
- Clarifying fasting-based dietary strategies: toward alignment with emerging consensus terminology.The Libyan journal of medicine · 2025Article
- Dialogue Between the Clock Gene Bmal1 and Retinopathy: What Is the Exact Relationship?CNS neuroscience & therapeutics · 2025Review
- Comparison of the Effects of Inappropriate Meal Timing-Induced and Genetic Models of Circadian Clock Disruption on Uterine mRNA Expression Profiles.The Journal of nutrition · 2024Article
- Sex-specific chrono-nutritional patterns and association with body weight in a general population in Spain (GCAT study).The international journal of behavioral nutrition and physical activity · 2024Article
- Some paradoxes and unresolved aspects of hepatic de novo lipogenesis.npj metabolic health and disease · 2024Review
- Circadian disruption, clock genes, and metabolic health.The Journal of clinical investigation · 2024Review
- Chronotype Differences in Body Composition, Dietary Intake and Eating Behavior Outcomes: A Scoping Systematic Review.Advances in nutrition (Bethesda, Md.) · 2022Article
- The Effects of Light and the Circadian System on Rhythmic Brain Function.International journal of molecular sciences · 2022Review
- Psychometric Testing of a Food Timing Questionnaire and Food Timing Screener.Current developments in nutrition · 2022Article
- Association of time of breakfast and nighttime fasting duration with breast cancer risk in the multicase-control study in Spain.Frontiers in nutrition · 2022Article
- Feeding and Eating Disorders in the Context of Circadian Rhythms.Alpha psychiatry · 2021Review
- Interconnections between circadian clocks and metabolism.The Journal of clinical investigation · 2021Review
- Alterations in Rev-ERBα/BMAL1 ratio and glycated hemoglobin in rotating shift workers: the EuRhythDia study.Acta diabetologica · 2021Article
- Delayed Meal Timing, a Breakfast Skipping Model, Increased Hepatic Lipid Accumulation and Adipose Tissue Weight by Disintegrating Circadian Oscillation in Rats Fed a High-Cholesterol Diet.Frontiers in nutrition · 2021Article
- Chrononutrition and Polyphenols: Roles and Diseases.Nutrients · 2019Review
- The circadian regulation of food intake.Nature reviews. Endocrinology · 2019Review
- Chronotype, social jet lag, sleep debt and food timing in inflammatory bowel disease.Sleep medicine · 2018Article
- Lipid metabolism in adipose tissue and liver from diet-induced obese rats: a comparison between Wistar and Sprague-Dawley strains.Journal of physiology and biochemistry · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelled
backgroundIn humans, skipping meals, especially breakfast, has been associated with obesity and other related syndromes. Recent studies in rodents suggest that fasting and feeding times are potential factors that affect the peripheral circadian clocks and metabolism. However, the link between fasting and obesity in rodents has yet to be fully demonstrated.
methodWe conducted early nocturnal fasting (ENF) from zeitgeber time (ZT) 12 to 18 for 4 consecutive days in C57B6 mice. The first set of experiments was performed under ad libitum conditions, where ENF and free-feeding (FF) control groups were compared. The second set was performed under isocaloric adjustment by restricting the diet to 90% of the basal intake of ENF mice. Calorie-restricted ENF (ENF-CR) mice were then compared with isocaloric controls (IC-control). Body weight, food intake, core body temperature, activity, adiposity, and clock-related gene expression levels in the liver and adipose tissues were investigated. A stable isotopic analysis was also conducted to estimate de novo lipogenesis fluxes.
resultsIn the ad libitum condition, the ENF mice ate more during the day, increased their overall daily food intake and gained more weight than FF-control mice. The amplitude of the body core temperature rhythm in ENF mice was also lower than in the FF-controls. Under isocaloric conditions, ENF-CR attenuated the CR-induced body weight loss, compared with the IC-control. ENF-CR also altered the acrophase time of the expression of the clock genes, which is associated with time-shift of genes involved in lipid metabolism and increased lipogenesis, compared with the IC-control.
conclusionsENF in nocturnal mice disturbs the peripheral clock and increases de novo lipid synthesis and results in a predisposition to obesity.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.