Evidence map›Paper›PMID 22962667›Full record

ReviewPhysical chemistry chemical physics : PCCP2012

Advances in functional X-ray imaging techniques and contrast agents.

Hongyu Chen, Melissa M Rogalski, Jeffrey N Anker

Abstract readReview
In one paragraph

Review in Physical chemistry chemical physics : PCCP, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Super Time-Resolved Tomography.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  6. Article
  7. Article
  8. MoSNanomaterials (Basel, Switzerland) · 2025
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hongyu ChenDepartment of Chemistry, Center for Optical Materials Science and Engineering Technology (COMSET), Clemson University, Clemson, SC 29634, USA.
Melissa M Rogalski
Jeffrey N Anker

Funding

Targeted Nano-therapeutics for Neural RegenerationP20GM103444 · NIGMS · CLEMSON UNIVERSITY · PI MARKWALD, ROGER R, VYAVAHARE, NAREN R · 2012 to 2018
$14.9M
UNDERSTANDING AND CONTROLLING TISSUE-SPECIFIC VASCULAR PATTERNINGP20RR021949 · NCRR · CLEMSON UNIVERSITY · PI MARKWALD, ROGER R · 2009 to 2011
$5.2M
NCRR NIH HHS 5P20RR021949NCRR NIH HHS P20 RR021949NIGMS NIH HHS 8P20GM103444NIGMS NIH HHS P20 GM103444
6 · The paper itself

Abstract

X-rays have been used for non-invasive high-resolution imaging of thick biological specimens since their discovery in 1895. They are widely used for structural imaging of bone, metal implants, and cavities in soft tissue. Recently, a number of new contrast methodologies have emerged which are expanding X-ray's biomedical applications to functional as well as structural imaging. These techniques are promising to dramatically improve our ability to study in situ biochemistry and disease pathology. In this review, we discuss how X-ray absorption, X-ray fluorescence, and X-ray excited optical luminescence can be used for physiological, elemental, and molecular imaging of vasculature, tumors, pharmaceutical distribution, and the surface of implants. Imaging of endogenous elements, exogenous labels, and analytes detected with optical indicators will be discussed.

Indexed as

LuminescenceTomography, X-Ray ComputedAnimalsContrast MediaHumansMicroscopy, FluorescenceNeoplasmsX-RaysContrast Media

Identifiers

PMID22962667
PMCPMC3569739

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.