ArticlePloS one2012
Production of organic acids by probiotic lactobacilli can be used to reduce pathogen load in poultry.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
107 citing papers in PubMed, 253 citations in OpenAlex.
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- Sources, Transmission, and Control of Salmonella in Vertically Integrated Broiler Chicken Production: Farm, Hatchery, and Processing Plant.Comprehensive reviews in food science and food safety · 2026Review
- Recombinant LAB vector-based multicomponent vaccine against Campylobacter jejuni potentially promoting a healthier microbial balance in the poultry gut.Microbiome · 2026Article
- Comparative efficacy of oral and cloacal administration of Lactobacillus probiotics and postbiotics against Campylobacter jejuni colonization in broiler chickens.Poultry science · 2026Article
- Lactococcus cremoris decreases virulence‑associated properties, and modifies the protein profile of foodborne pathogen Campylobacter jejuni in biofilm.Gut pathogens · 2026Article
- Fecal microbiome associated with egg production efficiency in laying hens.Animal bioscience · 2026Article
- Spectroscopic Techniques in Bacterial Analysis: Applications of FTIR and Raman-Review.Foods (Basel, Switzerland) · 2026Review
- Relationship BetweenVeterinary sciences · 2026Article
- Effectiveness of Interventions and Control Measures in the Reduction ofFoods (Basel, Switzerland) · 2026Review
- Direct-fed Microbials (DFM) and Poultry Genomics: A Synergistic Approach to Sustainable Antibiotic Free Farming.Probiotics and antimicrobial proteins · 2026Review
- Effect ofAnimals : an open access journal from MDPI · 2025Article
- Major Foodborne Bacterial Pathogens in Poultry: Implications for Human Health and the Poultry Industry and Probiotic Mitigation Strategies.Microorganisms · 2025Review
- Probiotic Potential of Lactic Acid Bacteria Isolated from Moroccan Traditional Food Products.Microorganisms · 2025Article
- Protecting DNA and improving freeze-drying survival rate of Lactiplantibacillus plantarum LIP-1 through metabolism of hypoxanthine.World journal of microbiology & biotechnology · 2025Article
- The Potential of Lactic Acid Bacteria and Dairy By-Products in ControllingMicroorganisms · 2025Review
- Review
- The host susceptibility/resistance-related genes and gut microbial characteristics inMicrobiology spectrum · 2025Article
- A Narrative Review on the Impact of Probiotic Supplementation on Muscle Development, Metabolic Regulation, and Fiber Traits Related to Meat Quality in Broiler Chickens.Microorganisms · 2025Review
- Antimicrobial Activity of Probiotic Bacteria Isolated from Plants: A Review.Foods (Basel, Switzerland) · 2025Review
- The Characterization of Lactic Acid Bacteria Strains as Components of a Biopreparation for Chickens for Slaughter.Microorganisms · 2025Article
47 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Probiotic Lactobacillus can be used to reduce the colonization of pathogenic bacteria in food animals, and therefore reduce the risk of foodborne illness to consumers. As a model system, we examined the mechanism of protection conferred by Lactobacillus species to inhibit C. jejuni growth in vitro and reduce colonization in broiler chickens. Possible mechanisms for the reduction of pathogens by lactobacilli include: 1) stimulation of adaptive immunity; 2) alteration of the cecal microbiome; and, 3) production of inhibitory metabolites, such as organic acids. The Lactobacillus species produced lactic acid at concentrations sufficient to kill C. jejuni in vitro. We determined that lactic acid produced by Lactobacillus disrupted the membrane of C. jejuni, as judged by biophotonics. The spectral features obtained using Fourier-transform infrared (FT-IR) and Raman spectroscopy techniques were used to accurately predict bacterial viability and differentiate C. jejuni samples according to lactic acid treatment. FT-IR spectral features of C. jejuni and Lactobacillus grown in co-culture revealed that the metabolism was dominated by Lactobacillus prior to the killing of C. jejuni. Based on our results, the development of future competitive exclusion strategies should include the evaluation of organic acid production.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.